Florant G L, Hoo-Paris R, Castex C, Bauman W A, Sutter B C
J Comp Physiol B. 1986;156(3):309-14. doi: 10.1007/BF01101092.
In euthermic and hibernating marmots (Marmota flaviventris), the pancreatic A and B cells respond in the appropriate secretory manner to glucose or arginine injection. Although reduced, this response, is clearly present in hibernating marmots. When glucose is administered to euthermic or hibernating marmots, plasma insulin concentrations rise and glucagon levels fall. While similar results are obtained in hibernation, the time period of the response is much longer due to the slowing of temperature dependent metabolic processes. Injection of L-arginine stimulates an increase in plasma glucose, insulin, and glucagon as expected. Measurements of plasma glucose, insulin, and glucagon under basal conditions, suggest that there are no significant differences between any phase of hibernation (eg. entrance, deep hibernation, arousal) and euthermia. These results provide indirect evidence that the pancreatic A and B cells of hibernating marmots continue to function in order to help regulate plasma glucose concentration.
在正常体温和冬眠的土拨鼠（黄腹土拨鼠）中，胰腺A细胞和B细胞会以适当的分泌方式对葡萄糖或精氨酸注射做出反应。尽管这种反应有所减弱，但在冬眠的土拨鼠中显然仍然存在。当给正常体温或冬眠的土拨鼠注射葡萄糖时，血浆胰岛素浓度会升高，胰高血糖素水平会下降。虽然在冬眠中也能得到类似的结果，但由于温度依赖性代谢过程的减慢，反应的时间段要长得多。注射L-精氨酸会如预期那样刺激血浆葡萄糖、胰岛素和胰高血糖素的增加。在基础条件下对血浆葡萄糖、胰岛素和胰高血糖素的测量表明，冬眠的任何阶段（如进入、深度冬眠、苏醒）与正常体温状态之间均无显著差异。这些结果提供了间接证据，表明冬眠土拨鼠的胰腺A细胞和B细胞继续发挥功能，以帮助调节血浆葡萄糖浓度。
