Kelleci Çakır Burcu, Kızılarslanoğlu Muhammet Cemal, Kılıç Mustafa Kemal, Tuna Doğrul Rana, Kuyumcu Mehmet Emin, Bayraktar Ekincioğlu Aygin, Başol Merve, Halil Meltem, Demirkan Kutay
Hacettepe University Faculty of Pharmacy, Department of Clinical Pharmacy, Ankara, Turkey
Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Ankara, Turkey
Turk J Pharm Sci. 2022 Feb 28;19(1):54-62. doi: 10.4274/tjps.galenos.2021.77010.
Appropriateness of the geriatric outpatients' medications needs special attention due to risks of falls, fractures, depression, hospital admissions and mortality. This study aimed to identify current practice on medication usage by using the 2 version of "Screening Tool of Older People's Potentially Inappropriate Prescriptions" and "Screening Tool to Alert Doctors to Right Treatment" criteria and affecting factors for the Turkish population.
This cross-sectional study was conducted between September 2015 and May 2016 at a university research and training hospital's geriatric outpatient clinic. Patients aged ≥65 years and had ≥5 different prescribed medications (considered as polypharmacy) were recruited. The main outcome measure was the frequency of inappropriate medications identified by clinical pharmacist in the outpatient clinic according to the 2 version of the criterion sets.
A total of 700 patients (440 female) were included in this study. According to the results, 316 patients (45.1%) with at least one potentially inappropriate medication and 668 patients (98.3%) with at least one potential prescription omission were detected. Potentially inappropriate medications were associated with the number of medications used per patient [odds ratio (OR): 1.20 <0.001], living alone (OR: 4.12 =0.02), and having congestive heart failure (OR: 2.41 <0.001). Twenty-two (27.5%) out of 80 criteria and 4 (11.8%) out of 34 criteria did not apply to the study population.
Detecting inappropriate medications to maintain treatment effectiveness is necessary to provide the optimum therapy. Despite the awareness of polypharmacy in outpatient clinics it is still one of the important causes of inappropriate prescription followed by vaccination rate. Therefore, with the contribution of clinical pharmacist using these available criteria is important, moreover modification of these criteria according to the local needs to be considered to achieve better outcomes.
由于老年门诊患者存在跌倒、骨折、抑郁、住院和死亡风险,其用药的合理性需要特别关注。本研究旨在使用“老年人潜在不适当处方筛查工具”和“提醒医生正确治疗筛查工具”的两个版本标准,确定土耳其人群用药的当前做法及影响因素。
本横断面研究于2015年9月至2016年5月在一所大学研究与培训医院的老年门诊进行。招募年龄≥65岁且有≥5种不同处方药物(视为多重用药)的患者。主要结局指标是临床药师在门诊根据两个版本的标准集确定的不适当药物的频率。
本研究共纳入700例患者(440例女性)。根据结果,检测到316例(45.1%)患者至少有一种潜在不适当药物,668例(98.3%)患者至少有一种潜在处方遗漏。潜在不适当药物与每位患者使用的药物数量[比值比(OR):1.20<0.001]、独居(OR:4.12=0.02)和患有充血性心力衰竭(OR:2.41<0.001)相关。80条标准中有22条(27.5%)、34条标准中有4条(11.8%)不适用于研究人群。
检测不适当药物以维持治疗效果对于提供最佳治疗是必要的。尽管门诊意识到多重用药问题,但它仍是不适当处方的重要原因之一,其次是疫苗接种率。因此,临床药师利用这些现有标准很重要,此外,应考虑根据当地需求修改这些标准以取得更好的结果。