Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Trends Neurosci. 2022 May;45(5):342-345. doi: 10.1016/j.tins.2022.02.001. Epub 2022 Feb 25.
The distribution of Alzheimer's disease (AD) tau pathology varies systematically and causes a diverse array of syndromes. This forum article provides a brief overview of key controversies in untangling the complexity of AD subtypes, explores potential causes of AD variability in the population, and discusses clinical relevance and future directions of research into AD heterogeneity.
阿尔茨海默病（AD）tau 病理学的分布具有系统性，会导致多种综合征。本文简要概述了在梳理 AD 亚型的复杂性方面存在的主要争议，探讨了 AD 变异性在人群中潜在的原因，并讨论了 AD 异质性研究的临床相关性和未来方向。
