From Department of Ophthalmology, Catholic University of Sacred-Heart Foundation "Policlinico Universitario A. Gemelli" IRCCS, Rome (T.C, G.D'A, A.S, G.A, U.DeV, S.R).
Department of NEUROFARBA, Ophthalmology, University of Florence, Careggi, Florence, Italy (R.T, L.G).
Am J Ophthalmol. 2022 Aug;240:30-36. doi: 10.1016/j.ajo.2022.02.014. Epub 2022 Feb 25.
To report the 1-year results of human amniotic membrane patch implantation for optic disc pit maculopathy.
A prospective, consecutive, interventional study.
Eleven eyes of 11 patients affected by optic disc pit maculopathy associated with subretinal/intraretinal fluid were included in this single-institution study. A 25-gauge pars plana vitrectomy was performed in all cases, with an implant of a human amniotic membrane patch into the optic disc pit and air was injected as endotamponade. The primary study outcome was the subretinal and intraretinal fluid reabsorption. Secondary outcomes were visual acuity improvement and postoperative complications.
Mean central retinal thickness gradually diminished from 512 ± 137 µm to 243 ± 19 µm, at the 12-month follow-up. The mean visual acuity improved from 20/80 at baseline to 20/32 at the 12-month follow-up. Complete fluid resorption occurred in 9 of 11 (81.8%) eyes and there was partial resorption in 2 eyes (18%). No subretinal fluid recurrence was observed during the 12-month follow-up. No intraoperative or postoperative complications were reported during the follow-ups. The amniotic membrane patch remained detectable inside the pit for the entire follow-up time.
An amniotic membrane plug may be effective for improving optic disc pit maculopathy. All cases had an anatomical improvement and encouraging visual acuity recovery.
报告人羊膜贴片植入治疗视盘小凹伴黄斑部视网膜下/视网膜内液的 1 年结果。
前瞻性、连续、干预性研究。
本单中心研究纳入了 11 例 11 只眼视盘小凹伴黄斑部视网膜下/视网膜内液的患者。所有病例均行 25G 标准经睫状体平坦部玻璃体切除术，在视盘小凹内植入人羊膜贴片，并注入空气作为内眼内压。主要研究终点为视网膜下和视网膜内液的吸收。次要终点为视力提高和术后并发症。
平均中央视网膜厚度从术前的 512 ± 137µm 逐渐减少至术后 12 个月的 243 ± 19µm。平均视力从基线时的 20/80 提高到术后 12 个月的 20/32。11 只眼中 9 只（81.8%）完全吸收，2 只（18.2%）部分吸收。在 12 个月的随访中，没有观察到视网膜下液的复发。在随访期间，没有观察到术中或术后并发症。羊膜贴片在整个随访期间都可在小凹内检测到。
羊膜塞可能对视盘小凹伴黄斑部视网膜下/视网膜内液有效。所有病例均有解剖学改善和令人鼓舞的视力恢复。
