一项关于经颅直流电刺激（tDCS）对精神分裂症一般精神病理学症状的荟萃分析综述；即刻改善后恢复基线。
A meta-analytic review of transcranial direct current stimulation (tDCS) on general psychopathology symptoms of schizophrenia; immediate improvement followed by a return to baseline.
机构信息
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA.
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA.
出版信息
Psychiatry Res. 2022 Apr;310:114471. doi: 10.1016/j.psychres.2022.114471. Epub 2022 Feb 22.
Abstract
Transcranial direct current stimulation (tDCS) is a promising tool for alleviating positive and negative symptoms of schizophrenia, but its role in functional outcome remains uncertain. This meta-analysis examined the effects of tDCS on general psychopathology symptoms (GPS) from the Positive and Negative Syndrome Scale (PANSS) because GPS are closely associated with daily functioning. Literature search using Medline and PsycINFO identified 8 randomized controlled trials with tDCS and PANSS. The GPS were significantly reduced after tDCS but there was no evidence for long-term treatment effects. Further research is needed to optimize the dosing of tDCS and to understand individual differences in treatment response.
摘要
经颅直流电刺激（tDCS）是一种有前途的工具，可以缓解精神分裂症的阳性和阴性症状，但它在功能结果中的作用仍不确定。这项荟萃分析检查了 tDCS 对阳性和阴性症状量表（PANSS）中一般精神病症状（GPS）的影响，因为 GPS 与日常功能密切相关。使用 Medline 和 PsycINFO 进行文献检索，确定了 8 项 tDCS 和 PANSS 的随机对照试验。GPS 在 tDCS 后显著降低，但没有长期治疗效果的证据。需要进一步研究来优化 tDCS 的剂量，并了解治疗反应的个体差异。
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