Division of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
University of Zurich, Raemistrasse 71, 8006, Zurich, Switzerland.
J Perinatol. 2022 Jul;42(7):885-891. doi: 10.1038/s41372-022-01356-y. Epub 2022 Feb 28.
Placental pathology might provide information on the etiology of hypoxic-ischemic encephalopathy (HIE). To evaluate the association of perinatal sentinel events (PSE), placental pathology and cerebral MRI in cooled neonates with moderate/severe HIE.
Retrospective analysis of 52 neonates with HIE registered in the Swiss National Asphyxia and Cooling Register 2011-2019. PSE and Non-PSE groups were tested for association with placental pathology. Placental pathology categories were correlated with MRI scores.
In total, 14/52 neonates (27%) had a PSE, 38 neonates (73%) did not have a PSE. There was no evidence for an association of occurrence of PSE and placental pathologies (p = 0.364). Neonates with high MRI scores tended to have more often chronic pathologies in their placentas than acute pathologies or normal placentas (p = 0.067).
Independent of the occurrence of PSE, chronic placental pathologies might be associated with more severe brain injury and needs further study.
胎盘病理学可能为缺氧缺血性脑病（HIE）的病因学提供信息。评估围产期哨兵事件（PSE）、胎盘病理学和冷却新生儿中中度/重度 HIE 的大脑 MRI 的相关性。
对 2011 年至 2019 年瑞士国家窒息和冷却登记处登记的 52 例 HIE 新生儿进行回顾性分析。对 PSE 和非 PSE 组进行了胎盘病理学关联测试。将胎盘病理分类与 MRI 评分相关联。
总共，14/52 名新生儿（27%）有 PSE，38 名新生儿（73%）没有 PSE。PSE 的发生与胎盘病理之间没有证据表明存在关联（p=0.364）。MRI 评分较高的新生儿其胎盘中慢性病变的发生率往往高于急性病变或正常胎盘（p=0.067）。
独立于 PSE 的发生，慢性胎盘病变可能与更严重的脑损伤有关，需要进一步研究。
