Fox Áine, Doyle Emma, Reynolds Adam, Geary Michael, Cuzzilla Rocco, Hayes Breda
Royal College of Surgeons (RCSI), Dublin, Ireland.
Department of Neonatology, Rotunda Hospital, Dublin, Ireland.
BMC Pediatr. 2025 Apr 14;25(1):294. doi: 10.1186/s12887-025-05652-2.
The role of the placenta in the development of hypoxic ischaemic encephalopathy (HIE) remains undefined. There is limited research comparing placental histology for infants with HIE and healthy controls. This is limiting our ability to understand its role in HIE. This study hypothesised that placental pathology is more common in infants with HIE compared with healthy infants and aimed to report the differences in placental histology between infants with HIE and healthy controls.
A case-control study of infants with moderate andsevere HIE and healthy controls at a single tertiary Neonatal Intensive Care Unit. Placental histology was reviewed by one perinatal histopathologist using consensus guidelines.
Seventy-four cases and 98 controls were included. Cases had a higher incidence of pathology, including fetal vascular malperfusion, histological chorioamnionitis and delayed villous maturation.
This study demonstrates a higher incidence of placental pathology for infants born with HIE suggesting that the placenta is an important factor in the pathogenesis of HIE. Further research is required to delineate this relationship.
胎盘在缺氧缺血性脑病（HIE）发展过程中的作用尚不明确。比较HIE婴儿与健康对照胎盘组织学的研究有限。这限制了我们理解其在HIE中作用的能力。本研究假设，与健康婴儿相比，HIE婴儿的胎盘病理情况更为常见，旨在报告HIE婴儿与健康对照之间胎盘组织学的差异。
在一家三级新生儿重症监护病房对中度和重度HIE婴儿及健康对照进行病例对照研究。由一名围产期组织病理学家按照共识指南对胎盘组织学进行评估。
纳入74例病例和98例对照。病例组的病理发生率较高，包括胎儿血管灌注不良、组织学绒毛膜羊膜炎和绒毛成熟延迟。
本研究表明，患HIE的婴儿胎盘病理发生率较高，提示胎盘是HIE发病机制中的一个重要因素。需要进一步研究来阐明这种关系。
