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一名青少年患者右上肺颗粒细胞瘤罕见病例。

A Rare Case of Granular Cell Tumor in the Right Upper Lung of an Adolescent Patient.

作者信息

Grove John, Meier Casey, Youssef Bahaaeldin, Costello Patrick

机构信息

Pathology, Lincoln Memorial University-DeBusk College of Osteopathic Medicine, Knoxville, USA.

Pathology, East Tennessee State University Quillen College of Medicine, Johnson City, USA.

出版信息

Cureus. 2022 Jan 24;14(1):e21558. doi: 10.7759/cureus.21558. eCollection 2022 Jan.

Abstract

Granular cell tumors (GCTs) are rare neoplasms of neuroectodermal origin characterized by large polygonal cells with abundant eosinophilic and granular cytoplasm. GCTs rarely affect the lungs, with only a few cases reported in the literature. The pathophysiology of this Schwann cell-derived condition is not well understood but is thought to be due to recurring genetic mutations. GCTs have been linked with Noonan syndrome. Here, we report the case of a 17-year-old caucasian male who presented with partial upper airway obstruction due to a GCT. This case promotes awareness among pathologists and clinicians for this condition in the workup of patients presenting with upper airway obstruction.

摘要

颗粒细胞瘤(GCTs)是一种罕见的神经外胚层起源的肿瘤,其特征是具有大量嗜酸性和颗粒状细胞质的大的多边形细胞。GCTs很少累及肺部,文献中仅报道了少数病例。这种源自施万细胞的疾病的病理生理学尚未完全了解,但认为是由于反复发生的基因突变所致。GCTs与努南综合征有关。在此,我们报告一例17岁白种男性患者,因GCT导致部分上呼吸道梗阻。该病例提高了病理学家和临床医生在对上呼吸道梗阻患者进行检查时对这种疾病的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7711/8865742/2cc42e44b9cd/cureus-0014-00000021558-i01.jpg

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