Department of Dermatology, Iwata City Hospital, Iwata, Japan.
J Dermatol. 2022 May;49(5):560-563. doi: 10.1111/1346-8138.16326. Epub 2022 Feb 28.
Immunoglobulin (Ig)A vasculitis/nephropathy is a systemic immune complex-mediated vasculitis. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is widely recommended in individuals without specific allergy to the vaccine components, it is arguable whether vaccination is advisable for patients with IgA vasculitis or for predisposed individuals. We and others have presented cases of IgA vasculitis occurring after SARS-CoV-2 vaccination. In total, these 19 cases, including ours, involved predominantly female patients, and half of them were suffering from de novo vasculitis onset. The most frequent manifestation was gross hematuria (89.5%) while skin lesions were relatively infrequent, occurring in only five cases (26.3%), of which three (15.8%) were confirmed to be IgA vasculitis. Taken together, these cases suggest that SARS-CoV-2 vaccination might be a trigger for development/deterioration of IgA vasculitis/nephropathy.
免疫球蛋白 A 血管炎/肾炎是一种系统性免疫复合物介导的血管炎。尽管严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗广泛推荐用于对疫苗成分无特定过敏的个体，但对于 IgA 血管炎患者或易感个体，接种疫苗是否可取仍存在争议。我们和其他人已经报告了接种 SARS-CoV-2 疫苗后发生 IgA 血管炎的病例。总的来说，这 19 例病例包括我们的病例，主要涉及女性患者，其中一半是新发病例。最常见的表现是肉眼血尿（89.5%），而皮肤病变相对较少，仅发生在 5 例（26.3%），其中 3 例（15.8%）被确认为 IgA 血管炎。综上所述，这些病例表明，SARS-CoV-2 疫苗接种可能是 IgA 血管炎/肾炎发展/恶化的一个诱因。
