急性冠状动脉综合征与肾功能损害：系统综述。
Acute coronary syndrome and renal impairment: a systematic review.
机构信息
Division of Cardiology, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Cardiology Unit, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psy-chology, Sapienza University of Rome, Sant'Andrea Hospital, 00189 Rome, Italy.
出版信息
Rev Cardiovasc Med. 2022 Feb 8;23(2):49. doi: 10.31083/j.rcm2302049.
BACKGROUND
Coronary artery disease (CAD) and chronic kidney disease (CKD) may reciprocally influence each other. Patients with CAD and CKD have an increased risk of both ischemic and hemorrhagic events.
METHODS
In the present review, we summarize the existing literature focusing on the relationship between kidney dysfunction and acute coronary syndromes (ACS) in terms of risk factors, complications, and prognosis. We discuss also about the best evidence-based strategies to prevent deterioration of renal function in patients with CAD.
RESULTS
Patients with CKD less frequently receive an invasive management (percutaneous or surgical revascularization) and potent antithrombotic drugs. Nevertheless, recent evidence suggests they would benefit from a selective invasive management, especially in case of ACS.
CONCLUSION
Patients with CKD and CAD represent a challenging population, more randomized controlled trials and meta-analyses are needed to better define the best therapeutic strategy during an ACS episode.
背景
冠心病（CAD）和慢性肾脏病（CKD）可能相互影响。CAD 和 CKD 患者发生缺血性和出血性事件的风险均增加。
方法
在本综述中，我们总结了现有文献，重点讨论了肾功能障碍与急性冠状动脉综合征（ACS）之间在危险因素、并发症和预后方面的关系。我们还讨论了预防 CAD 患者肾功能恶化的最佳循证策略。
结果
CKD 患者较少接受侵入性治疗（经皮或手术血运重建）和强效抗血栓药物。然而，最近的证据表明，他们可能受益于选择性的侵入性治疗，尤其是在 ACS 的情况下。
结论
CKD 和 CAD 患者是一个具有挑战性的人群，需要更多的随机对照试验和荟萃分析来更好地确定 ACS 发作期间的最佳治疗策略。
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