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海湾合作委员会国家终末期肾病的现状与未来:挑战与机遇。

Current Status and Future of End-Stage Kidney Disease in Gulf Cooperation Council Countries: Challenges and Opportunities.

机构信息

Cleveland Clinic Lerner College of Medicine of CWRU Cleveland Clinic, Ohio, USA.

Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.

出版信息

Saudi J Kidney Dis Transpl. 2021 Jul-Aug;32(4):1073-1088. doi: 10.4103/1319-2442.338281.

Abstract

There is a paucity of data on epidemiology along with an incomplete registry of end-stage kidney disease (ESKD), nephrologist workforce, and variability among the countries of Gulf Cooperation Council (GCC). The study is an observation, descriptive study which aimed to describe current ESKD burden, nephrologist density, and kidney care infrastructure in GCC. Responses to a questionnaire-based survey obtained from representatives of the Nephrology Societies of GCC countries were analyzed. The categorical variables were compared using Chi-square test. A P = 5% was considered as significant. The mean prevalence of ESKD per million populations (pmp) was 551, highest in Oman (1000/pmp), least in Qatar (347/pmp). Predominant etiology in GCC was diabetes mellitus (DM) and hypertension (HTN) (100%, each), followed by chronic glomerulonephritis (66.7%). A transplant registry was maintained by all GCC countries. Hemodialysis (HD) (67.2%) was the most opted modality of kidney replacement therapy (KRT), followed by kidney transplantation (22%) and peritoneal dialysis (9.6%); 1.0% of patients opted for conservative management. Unplanned initiation of HD was three times more common. The access distribution among incident and prevalent HD patients respectively was (i) nontunneled central catheter (nTCC) (58.7 ± 36.6 vs. 1.5 ± 1.5), (ii) tunneled central catheter (23.5 ± 29.9 vs. 33.6 ± 10.0), and (iii) arteriovenous fistula (17.3± 14.4 vs. 57.8 ± 11.86). Death and transplantation were the reasons for dropout from HD. GCC has adequate kidney care infrastructure. There are 1686 nephrologists [range: Bahrain 9, Kingdom of Saudi Arabia (KSA) 1279]. Qatar, KSA, and Kuwait provide training in kidney biopsy; all countries except Bahrain have formal training programs for nTCC placement. ESKD prevalence is high, DM, HTN; glome-rulonephritis (GN) is the most common causes. The need for KRT is expected to rise in GCC. HD is the predominant KRT modality with a high prevalence of dialysis catheters as vascular access.

摘要

该地区在流行病学方面的数据有限,终末期肾病(ESKD)登记不完整,肾脏病学家的劳动力以及海湾合作委员会(GCC)各国之间存在差异。这项研究是一项观察性、描述性研究,旨在描述 GCC 国家目前的 ESKD 负担、肾脏病学家密度和肾脏护理基础设施。对来自 GCC 国家肾脏病学会代表的基于问卷的调查的答复进行了分析。使用卡方检验比较了分类变量。 P = 5%被认为具有统计学意义。每百万人口的 ESKD 患病率(pmp)平均值为 551,其中阿曼最高(1000/pmp),卡塔尔最低(347/pmp)。GCC 的主要病因是糖尿病(DM)和高血压(HTN)(各 100%),其次是慢性肾小球肾炎(66.7%)。所有 GCC 国家均维持着移植登记处。血液透析(HD)(67.2%)是肾脏替代疗法(KRT)最常用的选择方式,其次是肾移植(22%)和腹膜透析(9.6%);1.0%的患者选择保守治疗。无计划开始 HD 的情况要多出三倍。新发病例和现有 HD 患者的通路分布分别为:(i)非隧道中央导管(nTCC)(58.7 ± 36.6 vs. 1.5 ± 1.5),(ii)隧道中央导管(23.5 ± 29.9 vs. 33.6 ± 10.0),和(iii)动静脉瘘(17.3± 14.4 vs. 57.8 ± 11.86)。死亡和移植是 HD 退出的原因。GCC 拥有足够的肾脏护理基础设施。有 1686 名肾脏病学家[范围:巴林 9 名,沙特阿拉伯王国(KSA)1279 名]。卡塔尔、KSA 和科威特提供肾脏活检培训;除巴林外,所有国家都有针对 nTCC 放置的正式培训计划。ESKD 的患病率很高,DM,HTN;GN 是最常见的病因。预计 GCC 对 KRT 的需求将会增加。HD 是主要的 KRT 方式,血管通路中透析导管的患病率很高。

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