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预测海湾合作委员会(GCC)国家 SARS-CoV-2 大流行和重症监护资源阈值:综合数据的人口分析。

Forecasting the SARS COVID-19 pandemic and critical care resources threshold in the Gulf Cooperation Council (GCC) countries: population analysis of aggregate data.

机构信息

Department of Statistics, Ministry of Higher Education, Muscat, Sultanate of Oman.

Centre of Studies and Research, Ministry of Health, Muscat, Sultanate of Oman.

出版信息

BMJ Open. 2021 May 11;11(5):e044102. doi: 10.1136/bmjopen-2020-044102.

Abstract

OBJECTIVE

To generate cross-national forecasts of COVID-19 trajectories and quantify the associated impact on essential critical care resources for disease management in Gulf Cooperation Council (GCC) countries.

DESIGN

Population-level aggregate analysis.

SETTING

Bahrain, Kuwait, Oman, Qatar, United Arab Emirates (UAE) and Saudi Arabia.

METHODS

We applied an extended time-dependent SEICRD compartmental model to predict the flow of people between six states, susceptible-exposed-infected-critical-recovery-death, accounting for community mitigation strategies and the latent period between exposure and infected and contagious states. Then, we used the WHO Adaptt Surge Planning Tool to predict intensive care unit (ICU) and human resources capacity based on predicted daily active and cumulative infections from the SEICRD model.

MAIN OUTCOME MEASURES

Predicted COVID-19 infections, deaths, and ICU and human resources capacity for disease management.

RESULTS

COVID-19 infections vary daily from 498 per million in Bahrain to over 300 per million in UAE and Qatar, to 9 per million in Saudi Arabia. The cumulative number of deaths varies from 302 per million in Oman to 89 in Qatar. UAE attained its first peak as early as 21 April 2020, whereas Oman had its peak on 29 August 2020. In absolute terms, Saudi Arabia is predicted to have the highest COVID-19 mortality burden, followed by UAE and Oman. The predicted maximum number of COVID-19-infected patients in need of oxygen therapy during the peak of emergency admissions varies between 690 in Bahrain, 1440 in Oman and over 10 000 in Saudi Arabia.

CONCLUSION

Although most GCC countries have managed to flatten the epidemiological curve by August 2020, trends since November 2020 show potential increase in new infections. The pandemic is predicted to recede by August 2021, provided the existing infection control measures continue effectively and consistently across all countries. Current health infrastructure including the provision of ICUs and nursing staff seem adequate, but health systems should keep ICUs ready to manage critically ill patients.

摘要

目的

生成 COVID-19 轨迹的跨国预测,并量化对海湾合作委员会(GCC)国家疾病管理所需关键重症监护资源的相关影响。

设计

人群水平的综合分析。

设置

巴林、科威特、阿曼、卡塔尔、阿拉伯联合酋长国(阿联酋)和沙特阿拉伯。

方法

我们应用扩展的时变 SEICRD compartmental 模型来预测六个州之间的人群流动,易感-暴露-感染-关键-恢复-死亡,考虑社区缓解策略以及暴露与感染和传染性状态之间的潜伏期。然后,我们使用世界卫生组织 Adaptt 应急规划工具根据 SEICRD 模型预测的每日活跃和累积感染来预测重症监护病房(ICU)和人力资源能力。

主要观察指标

预测的 COVID-19 感染、死亡以及 ICU 和人力资源疾病管理能力。

结果

COVID-19 感染每天从巴林的每百万 498 例到阿联酋和卡塔尔的每百万超过 300 例,再到沙特阿拉伯的每百万 9 例不等。死亡人数从阿曼的每百万 302 例到卡塔尔的 89 例不等。阿联酋早在 2020 年 4 月 21 日就达到了第一个高峰,而阿曼则在 2020 年 8 月 29 日达到了高峰。就绝对数量而言,沙特阿拉伯预计 COVID-19 死亡率最高,其次是阿联酋和阿曼。在紧急入院高峰期需要氧疗的 COVID-19 感染患者的预计最高人数在巴林为 690 人,阿曼为 1440 人,沙特阿拉伯为 10000 多人。

结论

尽管大多数 GCC 国家在 2020 年 8 月前成功地使疫情曲线变平,但自 2020 年 11 月以来的趋势显示出新感染病例有潜在增加。如果所有国家继续有效地、一致地实施现有的感染控制措施,预计疫情将在 2021 年 8 月消退。目前的卫生基础设施,包括 ICU 和护理人员的提供,似乎足够,但卫生系统应保持 ICU 为治疗重症患者做好准备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0400/8117473/01ea5e90e2d7/bmjopen-2020-044102f01.jpg

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