Department of Pharmacognosy, College of Pharmacy, King Khalid University (KKU), Abha, Kingdom of Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, King Khalid University (KKU), Abha, Kingdom of Saudi Arabia.
Nat Prod Res. 2023 May;37(9):1550-1556. doi: 10.1080/14786419.2022.2025594. Epub 2022 Mar 1.
Phytochemical analyses of the chloroform extract of L. var. , Piperaceae, leaves led to the isolation of a new phenylpropanoid analogue for the first time: hydroxychavicol dimer, 2-('-hydroxychavicol)-hydroxychavicol (), on the basis of spectroscopic data 1 D (H and C) and 2 D (H-H COSY and HMBC) NMR, as well as ESI-MS, FT-IR, HR-ESI-MS and LC-ESI-MS. Compound exhibited excellent antioxidant DPPH radical scavenging activity with IC values of 9.07 μg/mL, compared to ascorbic acid as a standard antioxidant drug with IC value of 3.41 μg/mL. Evaluation of cytotoxic activity against two human colon cancer cell lines (HT 29 and COLO-205) showed significant effect with GI values of 73.81 and 64.02 μmol/L, compared to Doxorubicin® as a standard cytotoxic drug with GI value of <10 μmol/L.
从胡椒科 L. var. 的氯仿提取物中进行的植物化学分析首次分离出一种新的苯丙素类似物： hydroxychavicol 二聚体，2-('-羟基黄樟素）-羟基黄樟素（），基于光谱数据 1D (H 和 C) 和 2D (H-H COSY 和 HMBC) NMR 以及 ESI-MS、FT-IR、HR-ESI-MS 和 LC-ESI-MS。与标准抗氧化药物抗坏血酸的 IC 值 3.41μg/mL 相比，化合物 表现出出色的抗氧化 DPPH 自由基清除活性，IC 值为 9.07μg/mL。对两种人结肠癌细胞系（HT 29 和 COLO-205）的细胞毒性活性评估显示，GI 值分别为 73.81 和 64.02μmol/L，与标准细胞毒性药物阿霉素（GI 值 <10μmol/L）相比具有显著效果。
