Eskandarieh Sharareh, Heydarpour Pouria, Elhami Seyedeh-Robab, Sahraian Mohammad Ali
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2017 May;46(5):699-704.
Tehran is the capital of Iran with an increasing Multiple Sclerosis (MS) incidence. A retrospective population-based study was conducted to evaluate the status of MS prevalence and MS incidence trends in Tehran Province, Iran.
A population-based study was conducted from 1991 to 2014 in Tehran Province, the capital city of Iran based on Iranian MS Society (IMSS) registry system. A structured questionnaire design to cover the important epidemiological variables, related at the individual level for MS. A Monte Carlo Permutation method was utilized to test whether the apparent change in MS trends during 1991-2014 was statistically significant.
MS incidence was significantly increased during our study period. The annual percent change (APC) was 12.8% in women during 1991 to 2004 and 12.5% in men during the same period. The point prevalence of MS was 101.39 per 100000 populations in 2014. The age-adjusted prevalence rates were 134.03 and for male patients were 42.45 per 100000.
MS prevalence and incidence in Tehran are markedly rising, it is crucial to elucidate the causes of the increasing trends and implement efficient policies lowering disease burden.
德黑兰是伊朗首都，多发性硬化症（MS）发病率呈上升趋势。开展了一项基于人群的回顾性研究，以评估伊朗德黑兰省MS患病率及发病趋势情况。
1991年至2014年在伊朗首都德黑兰省基于伊朗多发性硬化症协会（IMSS）登记系统开展了一项基于人群的研究。设计了一份结构化问卷，涵盖与MS个体层面相关的重要流行病学变量。采用蒙特卡洛排列法检验1991 - 2014年期间MS趋势的明显变化是否具有统计学意义。
在我们的研究期间，MS发病率显著增加。1991年至2004年期间，女性的年变化百分比（APC）为12.8%，同期男性为12.5%。2014年MS的点患病率为每10万人口101.39例。年龄调整后的患病率为每10万人口134.03例，男性患者为42.45例。
德黑兰的MS患病率和发病率显著上升，阐明上升趋势的原因并实施有效政策降低疾病负担至关重要。
