Ferrante A, Jenkin C R, Reade P C
Aust J Exp Biol Med Sci. 1978 Feb;56(1):47-59. doi: 10.1038/icb.1978.6.
Data presented show that during the course of a Trypanosoma lewisi infection in rats there was both an activation of the phagocytic cells of the liver and spleen and an increase in their numbers. There was a marked lymphoid hyperplasia in the white pulp of the spleen with an increase in the number and size of the lymphoid follicles. Degenerative changes occurred in the liver parenchymal cells during the infection, and at certain stages large numgers of mononuclear cells were observed in the vascular sinusoids and other vessels of the liver.
所呈现的数据表明，在大鼠感染路氏锥虫的过程中，肝脏和脾脏的吞噬细胞既被激活，其数量也有所增加。脾脏白髓出现明显的淋巴样增生，淋巴滤泡的数量和大小均增加。感染期间肝脏实质细胞发生退行性变化，在某些阶段，在肝脏的血管窦和其他血管中观察到大量单核细胞。
