Murray P K, Jennings F W, Murray M, Urquhart G M
Immunology. 1974 Nov;27(5):815-24.
The functional integrity of the mononuclear phagocytic system (MPS) in mice infected with was investigated with regard to its possible significance in the aetiology of the immunosuppression characteristic of this disease. In infected mice the spleens and lymph nodes were grossly enlarged, and on histological examination it was shown that the MPS of the liver, lymph nodes, spleen and bone marrow was markedly expanded. Macrophages presented an active appearance and often contained cellular debris. Clearance of intravenously injected sheep red blood cells (SRBC) was increased, in that 1 hour after injection, 2–6 times more Cr-labelled SRBC had disappeared from the circulation of infected, compared to uninfected mice; this was due largely to an increased uptake by the expanded phagocytic system of the liver. The intrinsic immunogenic potential of individual macrophages appeared to be unimpaired as judged by the ability of SRBC-containing macrophages from infected mice to elicit a response in syngeneic normal recipient mice. It was concluded that the only evidence that immunosuppression might be associated with an altered activity of the MPS was an increased hepatic uptake of particulate antigen with a relative failure of splenic uptake. Together these might be responsible for a reduction in the concentration of antigen in the tissues of an enlarged spleen below the level necessary to initiate the formation of antibody.
研究了感染[病原体名称未给出]的小鼠单核吞噬细胞系统（MPS）的功能完整性，探讨其在该疾病免疫抑制病因学中可能具有的意义。感染小鼠的脾脏和淋巴结明显肿大，组织学检查显示肝脏、淋巴结、脾脏和骨髓的MPS显著扩张。巨噬细胞呈现活跃状态，且常含有细胞碎片。静脉注射绵羊红细胞（SRBC）后的清除率增加，即注射1小时后，与未感染小鼠相比，感染小鼠循环中消失的铬标记SRBC多2至6倍；这主要是由于肝脏中扩张的吞噬系统摄取增加所致。从感染小鼠中获取的含SRBC巨噬细胞在同基因正常受体小鼠中引发反应的能力表明，单个巨噬细胞的内在免疫原性潜力似乎未受损害。得出的结论是，免疫抑制可能与MPS活性改变相关的唯一证据是肝脏对颗粒抗原的摄取增加，而脾脏摄取相对不足。这两者共同作用可能导致肿大脾脏组织中抗原浓度降低至启动抗体形成所需水平以下。
