Ananth J, Lin K M
Neuropsychobiology. 1986;15(1):20-7. doi: 10.1159/000118236.
There are speculations that beta-adrenergic blocking agents are useful in the treatment of psychiatric disorders. Clinically, propranolol, an agent of this group, has been investigated in the treatment of various clinical disorders including schizophrenia, other psychoses, anxiety disorders, and stress reactions. This paper critically evaluates its efficacy in these disorders and provides a useful clinical perspective. In addition, propranolol produces a number of psychiatric side effects which are due to its central action or due to the peripheral receptor blockade. In addition, idiosyncratic reactions as well as withdrawal effects have also been reported to produce psychiatric side effects. It is important that the physician who wishes to use this drug know the existing knowledge of its usefulness in the treatment of psychiatric disorders as well as its psychiatric side effects.
有推测认为β-肾上腺素能阻滞剂在治疗精神疾病方面有用。临床上，该类药物中的普萘洛尔已被用于研究治疗包括精神分裂症、其他精神病、焦虑症和应激反应在内的各种临床疾病。本文批判性地评估了其在这些疾病中的疗效，并提供了有用的临床观点。此外，普萘洛尔会产生一些精神方面的副作用，这些副作用要么是由于其中心作用，要么是由于外周受体阻滞。此外，还报道了特异反应以及撤药效应也会产生精神方面的副作用。希望使用这种药物的医生了解其在治疗精神疾病方面的现有有用知识以及其精神方面的副作用是很重要的。
