Johnson J M
J Nerv Ment Dis. 1984 Mar;172(3):123-32. doi: 10.1097/00005053-198403000-00001.
Most clinicians are aware of the unwanted behavioral effects which may accompany the use of drugs that affect noradrenergic functioning in the treatment of hypertension. However, it is not generally appreciated by psychiatrists that these drugs have many potential therapeutic uses in psychiatry and are potent adjuncts to traditional psychotropic drugs. When administered appropriately by a psychiatrist, antiadrenergic and adrenergic blocking drugs can be used for treatment of disorders of thought, mood, anxiety, and movement. This paper reviews the pharmacology of four of these medications. The literature is reviewed for each drug. Although the mechanisms of action of these antihypertensives differ, their common effects on noradrenergic functioning often result in behavioral changes.
大多数临床医生都知道，在治疗高血压时使用影响去甲肾上腺素能功能的药物可能会伴随不良行为效应。然而，精神科医生一般并不普遍认识到这些药物在精神病学中有许多潜在的治疗用途，并且是传统精神药物的有效辅助药物。当由精神科医生适当地给药时，抗肾上腺素能和肾上腺素能阻断药物可用于治疗思维、情绪、焦虑和运动障碍。本文综述了其中四种药物的药理学。对每种药物的文献进行了综述。尽管这些抗高血压药物的作用机制不同，但它们对去甲肾上腺素能功能的共同影响往往会导致行为改变。
