[Effect of different glucocorticoids on the in vitro cell kinetics of human hematopoiesis represented by a bone marrow culture and by phytohemagglutinin- and pokeweed mitogen-stimulated blood cultures].

The effect of nine glucocorticoids, DHEA, cyclohexanol and dextran sulphate on the hematopoietic proliferation was investigated. Three glucocorticoids inhibited the proliferation of normal bone marrow cells, the others enhanced it. The T-cell stimulation was not inhibited by fluorcortolone contrary to prednisolone. Specially the proliferation of acute myeloid leukemic blasts was inhibited by fluorcortolone hemisulfate, which significantly stimulated the proliferation of normal bone cells.