NICM Health Research Institute, Western Sydney University, Westmead, New South Wales, Australia.
The Florey Institute of Neuroscience and Mental Health & Department of Psychiatry, Melbourne University, Melbourne, Victoria, Australia.
Ann N Y Acad Sci. 2022 Jun;1512(1):5-9. doi: 10.1111/nyas.14764. Epub 2022 Mar 1.
Disruptive innovation is a cornerstone of various disciplines, particularly in the business world, where paradigm-altering approaches are often lauded. As a construct, disruptive psychiatry can be considered to embody such an approach by the pursuit of innovations within the field which test boundaries and shake up the status quo. Given the importance of addressing the current mental health pandemic, and the deficit of highly effective pharmacological treatments for various conditions, innovative disruptive thinking is required. Significant promise exists via the provision of potentially more effective innovative therapeutic options, including digital interventions, psychedelic medicines, microbiome-altering treatments, brain stimulation technology, and nanotechnology-based delivery systems. These approaches may be further advanced by individualization of the treatments using computational technology (including quantum computing, machine learning, and artificial intelligence) and genomics.
颠覆性创新是多个学科的基石，尤其是在商业领域，颠覆性的方法常常受到赞誉。作为一种构建方式，颠覆性精神病学可以被视为通过在该领域内追求创新来体现这种方法，这些创新检验了边界并颠覆了现状。鉴于解决当前精神健康流行病的重要性，以及各种情况下缺乏高度有效的药物治疗方法，需要具有创新性的颠覆性思维。通过提供潜在更有效的创新治疗选择，包括数字干预、迷幻药物、改变微生物组的治疗方法、脑刺激技术和基于纳米技术的输送系统，存在着巨大的希望。通过使用计算技术（包括量子计算、机器学习和人工智能）和基因组学对治疗方法进行个体化，可以进一步推进这些方法。
