Dynamic contrast-enhanced MRI can quantitatively identify malignant transformation of sinonasal inverted papilloma.

OBJECTIVE

To investigate the diagnostic performance of quantitative and semi-quantitative parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) in differentiating sinonasal inverted papilloma (SIP) from SIP with coexisting malignant transformation into squamous cell carcinoma (MT-SIP).

METHODS

This retrospective study included 122 patients with 88 SIP and 34 MT-SIP. Quantitative and semi-quantitative parameters derived from DCE-MRI were compared between SIP and MT-SIP. The multivariate logistic regression analysis was performed to identify independent indicators and construct regression model for distinguishing MT-SIP and SIP. Diagnostic performance of independent indicators and regression model were evaluated using receiver operating coefficient (ROC) analysis and compared using DeLong test.

RESULTS

There were significant differences in maximum slope of increase, contrast-enhancement ratio, bolus arrival time, volume of extravascular extracellular space (V), and rate constant (K) between SIP and MT-SIP ( < 0.05). There were no significant differences in initial area under the gadolinium curve ( = 0.174) and volume transfer constant ( = 0.105) between two groups. Multivariate analysis results showed that V and K were identified as the independent indicators for differentiating MT-SIP from SIP ( < 0.001). Areas under the ROC curves (AUCs) for predicting MT-SIP were 0.779 for V and 0.766 for K. The AUC of the combination of V and K was 0.831, yielding 83% specificity and 76.5% sensitivity.

CONCLUSION

DCE-MRI can quantitatively differentiate between MT-SIP and SIP. The combination of V and K yielded an optimal performance for discriminating SIP from its malignant mimics.

ADVANCES IN KNOWLEDGE

DCE-MRI with quantitative and semi-quantitative parameters can provide valuable evidences for quantitatively identifying MT-SIP.