中国广西壮族自治区两例感染甲型禽流感（H5N6）病毒的人类病例的基因特征分析 - 2021年
Genetic Characterization of Two Human Cases Infected with the Avian Influenza A (H5N6) Viruses - Guangxi Zhuang Autonomous Region, China, 2021.
作者信息
Bi Fuyin, Jiang Lili, Huang Lihua, Wei Jingguang, Pan Xiaowen, Ju Yu, Mo Jianjun, Chen Minmei, Kang Ning, Tan Yi, Li Yonghong, Wang Jing
机构信息
Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, Guangxi Zhuang Autonomous Region, China.
Guilin Center for Disease Control and Prevention, Guilin, Guangxi Zhuang Autonomous Region, China.
出版信息
China CDC Wkly. 2021 Oct 29;3(44):923-928. doi: 10.46234/ccdcw2021.199.
WHAT IS KNOWN ABOUT THIS TOPIC?: H5N6 has replaced H5N1 as a dominant avian influenza virus (AIV) subtype in southern China. The increasing genetic diversity and geographical distribution of H5N6 pose a serious threat to the poultry industry and human health.
WHAT IS ADDED BY THIS REPORT?: A total of 2 cases of H5N6 that occurred from February 2021 to July 2021 in Guangxi, China were reported in this study. Phylogenetic analysis of gene was constructed, and some mutations of HA gene, PB2 gene, PA gene, M1 gene, NS1 gene, the receptor-binding site were detected. The evolutionary origins of the internal genes were different.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: As a multi-source reassortant virus, the H5N6 highly pathogenic AIV is continuously evolving. There is an urgent need to strengthen the surveillance of drug-resistant strains and novel variants.
关于该主题已知的信息
H5N6已取代H5N1成为中国南方主要的禽流感病毒（AIV）亚型。H5N6不断增加的基因多样性和地理分布对家禽业和人类健康构成严重威胁。
本报告补充的内容
本研究报告了2021年2月至2021年7月在中国广西发生的2例H5N6病例。构建了基因系统发育分析，并检测到HA基因、PB2基因、PA基因、M1基因、NS1基因、受体结合位点的一些突变。内部基因的进化起源不同。
对公共卫生实践的启示
作为一种多源重组病毒，H5N6高致病性禽流感病毒在不断进化。迫切需要加强对耐药菌株和新型变体的监测。
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