Hatch D, Overturf G D, Kovacs A, Forthal D, Leong C
Pediatr Infect Dis. 1986 Jul-Aug;5(4):416-20. doi: 10.1097/00006454-198607000-00007.
Ceftazidime was prospectively evaluated in the treatment of bacterial meningitis in 19 pediatric patients. Haemophilus influenzae type b (HIB) was the etiologic agent in 17 patients, and Streptococcus pneumonia and Neisseria meningitidis were the etiologic agents in one patient each. Ceftazidime was administered intravenously in a dosage of 150 mg/kg/day divided into eight hourly doses for a mean of 15 days (range, 14 to 22 days) for H. influenzae type b meningitis. The clinical and microbiologic response was appropriate in all cases. The mean ceftazidime CSF concentration was 6.7 micrograms/ml at approximately 2 hours following iv infusions. This concentration was 16- to greater than 100-fold the minimal bactericidal concentration determined for the isolated pathogens. These preliminary observations support ceftazidime as a candidate cephalosporin for the treatment of bacterial meningitis caused by H. influenzae. Additional study is required to further define its role in meningitis caused by S. pneumoniae and N. meningitidis.
前瞻性评估了头孢他啶对19例儿科细菌性脑膜炎患者的治疗效果。17例患者的病原体为b型流感嗜血杆菌（HIB），1例患者的病原体为肺炎链球菌，另1例患者的病原体为脑膜炎奈瑟菌。对于b型流感嗜血杆菌脑膜炎，头孢他啶静脉给药剂量为150mg/kg/天，分8次给药，每小时1次，平均给药15天（范围为14至22天）。所有病例的临床和微生物学反应均良好。静脉输注后约2小时，脑脊液中头孢他啶的平均浓度为6.7μg/ml。该浓度是所分离病原体最低杀菌浓度的16至100倍以上。这些初步观察结果支持头孢他啶作为治疗由b型流感嗜血杆菌引起的细菌性脑膜炎的候选头孢菌素。需要进一步研究以明确其在肺炎链球菌和脑膜炎奈瑟菌引起的脑膜炎中的作用。
