Tessin I, Trollfors B, Thiringer K, Thörn Z, Larsson P
Department of Paediatrics, Mölndal's Hospital, Sweden.
Eur J Pediatr. 1989 Jun;148(7):679-81. doi: 10.1007/BF00441533.
Thirty-five neonates with suspected septicaemia were randomized to treatment with tobramycin or ceftazidime, both in combination with ampicillin. Concentrations of antibiotics in the CSF were measured 1 h after the third, fourth or fifth injection. In 13 of 17 neonates tobramycin CSF concentrations were below 0.5 mg/l. Ceftazidime CSF concentrations ranged from 2.5 to 17 mg/l, which should be sufficient for treatment of infections with group B streptococci and most aerobic gram-negative bacilli but not all strains of Staphylococcus aureus. Ampicillin CSF concentrations ranged from 1 to 80 mg/l, which should be sufficient for treatment of meningitis caused by enterococci and Listeria monocytogenes, the most important neonatal pathogens not covered by ceftazidime.
35名疑似败血症的新生儿被随机分为两组，分别接受妥布霉素或头孢他啶治疗，两种药物均与氨苄西林联合使用。在第三次、第四次或第五次注射后1小时测量脑脊液中的抗生素浓度。17名新生儿中有13名的妥布霉素脑脊液浓度低于0.5mg/l。头孢他啶脑脊液浓度范围为2.5至17mg/l，这对于治疗B组链球菌和大多数需氧革兰氏阴性杆菌感染应该足够，但对所有金黄色葡萄球菌菌株则不够。氨苄西林脑脊液浓度范围为1至80mg/l，这对于治疗由肠球菌和单核细胞增生李斯特菌引起的脑膜炎应该足够，这两种菌是头孢他啶未覆盖的最重要的新生儿病原体。
