School of Medicine, University of Auckland, Auckland, New Zealand.
Department of Neurosurgery, Yuquan Hospital Affiliated to Tsinghua University School of Clinical Medicine, Beijing, People's Republic of China.
Diabetes. 2022 Jun 1;71(6):1182-1192. doi: 10.2337/db21-0976.
A growing body of evidence suggests that intrapancreatic fat is associated with diabetes, but whether distribution of intrapancreatic fat across the regions of the pancreas has a pathophysiologic role is unknown. The aim of this study was to investigate the differences in intrapancreatic fat deposition between the head, body, and tail of the pancreas, as well as the relationship between regional intrapancreatic fat deposition and diabetes status and insulin traits. A total of 368 adults from the general population underwent MRI on a 3 Tesla scanner, and intrapancreatic fat was manually quantified in duplicate. Statistical models included adjustment for age, sex, ethnicity, BMI, and liver fat. Intrapancreatic fat deposition in the head, body, and tail of the pancreas did not differ significantly in adjusted models in either the overall cohort or the three subgroups based on diabetes status. HOMA of insulin resistance and fasting insulin were significantly positively associated with fat in the tail and body of the pancreas. There was no significant association between regional intrapancreatic fat and HOMA of β-cell function. The association of increased intrapancreatic fat deposition in the tail and body regions with increased insulin resistance may have an important role in the early identification of patients at risk for developing insulin resistance and diseases that stem from it.
越来越多的证据表明，胰内脂肪与糖尿病有关，但胰内脂肪在胰腺各区域的分布是否具有病理生理作用尚不清楚。本研究旨在探讨胰头、胰体和胰尾胰内脂肪沉积的差异，以及区域性胰内脂肪沉积与糖尿病状态和胰岛素特征之间的关系。共有 368 名来自普通人群的成年人在 3 Tesla 扫描仪上进行了 MRI 检查，并对胰内脂肪进行了两次手动定量。统计模型包括年龄、性别、种族、BMI 和肝脂肪的调整。在调整后的模型中，无论是在整个队列中还是根据糖尿病状态分为三组，胰头、胰体和胰尾的胰内脂肪沉积均无显著差异。胰岛素抵抗的 HOMA 和空腹胰岛素与胰尾和胰体的脂肪呈显著正相关。区域性胰内脂肪与胰岛β细胞功能的 HOMA 之间没有显著关联。胰尾和胰体区域胰内脂肪沉积增加与胰岛素抵抗增加之间的关联可能对早期识别有发生胰岛素抵抗及其相关疾病风险的患者具有重要作用。
