Division of Hematology/Oncology/Blood and Marrow Transplantation, Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin.
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.
J Pediatr Hematol Oncol. 2022 Jul 1;44(5):268-270. doi: 10.1097/MPH.0000000000002437. Epub 2022 Mar 1.
Donor cell leukemia is a rare complication following hematopoietic stem cell transplant (HSCT). There are currently few reports in children and only rare, reported cases of donor-derived myelodysplastic syndrome/acute myeloid leukemia in patients with an underlying germline GATA2 mutation. Most reported cases are myeloid in origin and occur following related HSCT. We present a 3-year-old female who developed a donor-derived B-cell acute lymphoblastic leukemia 2 years post unrelated HSCT for GATA2 germline mutation.
供体细胞白血病是造血干细胞移植（HSCT）后一种罕见的并发症。目前在儿童中仅有少数报道，并且在存在种系 GATA2 突变的患者中仅有极少数报道的供体衍生骨髓增生异常综合征/急性髓系白血病病例。大多数报道的病例起源于骨髓，并在相关 HSCT 后发生。我们报告了一例 3 岁女性，在无关 HSCT 后 2 年因 GATA2 种系突变而发生供体衍生 B 细胞急性淋巴细胞白血病。
