Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Department of Pathophysiology, Internal Medicine, Ankara University Medical School, Ankara, Turkey.
Gynecol Endocrinol. 2022 Apr;38(4):329-332. doi: 10.1080/09513590.2022.2045937. Epub 2022 Mar 3.
We aimed to compare maternal serum midkine level in pregnant women with different types of diabetes mellitus (DM) and healthy pregnant women. We also assessed maternal serum midkine level performance to predict adverse neonatal outcomes in the DM group.
The study included 57 pregnant women diagnosed with gestational diabetes mellitus (GDM) and 41 pregnant women with preexisting DMThe control group consisted of 98 healthy pregnant women.
Serum midkine level is higher in the DM group than healthy ones (0.93 ± 0.8 vs. 0.23 ± 0.2, <.001). When the diabetic groups were compared, the highest serum midkine level was found in GDM, followed by Type 1 DM and Type 2 DM (1.33 ± 0.9 ng/ml, 0.58 ± 0.5 ng/ml vs. 0.30 ± 0.2, respectively). Maternal serum midkine level was higher in the DM group with adverse perinatal outcomes than those without adverse outcomes, but there was no statistical difference (0.97 ± 0.91vs. 0.87 ± 0.73, =.571).
Serum midkine level was significantly higher in pregnant women with GDM, Type 1, and 2 DM than healthy ones. Serum midkine level did not predict adverse neonatal outcomes in the DM group.
比较不同类型糖尿病（DM）孕妇与健康孕妇的血清中期因子水平。我们还评估了母体血清中期因子水平对预测 DM 组不良新生儿结局的性能。
研究纳入了 57 名诊断为妊娠期糖尿病（GDM）的孕妇和 41 名患有糖尿病的孕妇，对照组由 98 名健康孕妇组成。
DM 组血清中期因子水平高于健康组（0.93±0.8 与 0.23±0.2，<0.001）。当比较糖尿病组时，GDM 组血清中期因子水平最高，其次是 1 型 DM 和 2 型 DM（1.33±0.9ng/ml、0.58±0.5ng/ml 与 0.30±0.2ng/ml）。DM 组中伴有不良围产结局的孕妇血清中期因子水平高于无不良结局者，但无统计学差异（0.97±0.91 与 0.87±0.73，=.571）。
GDM、1 型和 2 型 DM 孕妇血清中期因子水平明显高于健康孕妇。血清中期因子水平不能预测 DM 组的不良新生儿结局。
