Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Boutalamine, Errachidia, 52000, Morocco.
Cardiovasc Hematol Agents Med Chem. 2022;20(3):219-236. doi: 10.2174/1871525720666220302125242.
The study aimed to assess the antihypertensive activity of Calamintha officinalis.
Calamintha officinalis (CO) is a medicinal and aromatic herb as well as an antihypertensive plant that is widely used for its medicinal properties in several regions.
This study aimed to evaluate the effect of the aqueous extract of Calamintha officinalis (AECO) on vasorelaxant activity and arterial blood pressure under normal and hypertensive states in rats. Additionally, the effect of AECO on vascular angiotensin-converting enzyme 2 (ACE-2) was assessed.
In the current study, AECO (100 mg/Kg) was prepared, and its antihypertensive ability was assessed in L-N-Nitro arginine methyl ester (L-NAME)-induced hypertensive rats. Blood pressure and heart rate were recorded for 6 h for the acute experiment and during seven days for the subchronic treatment.
The results indicated that AECO reduced the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. In addition, the study showed that AECO exerts a vasorelaxant ability through the sGC-cGMP induction pathway, vascular cyclooxygenase pathway, and the opening of K+ channels. However, AECO had no inhibitory effect on aortic ACE-2.
The study illustrates the beneficial action of AECO as an antihypertensive and vasorelaxant agent.
本研究旨在评估夏香薄荷的降压活性。
夏香薄荷（CO）是一种药用和芳香草本植物，也是一种降压植物，因其药用特性在多个地区被广泛使用。
本研究旨在评估夏香薄荷水提物（AECO）对正常和高血压状态下大鼠血管舒张活性和动脉血压的影响。此外，还评估了 AECO 对血管血管紧张素转换酶 2（ACE-2）的影响。
在本研究中，制备了 AECO（100mg/Kg），并在 L-N-硝基精氨酸甲酯（L-NAME）诱导的高血压大鼠中评估其降压能力。急性实验记录血压和心率 6 小时，亚慢性治疗期间记录 7 天。
结果表明，AECO 降低了高血压大鼠的收缩压、舒张压和平均动脉血压。此外，研究表明，AECO 通过 sGC-cGMP 诱导途径、血管环氧化酶途径和 K+通道的开放发挥血管舒张作用。然而，AECO 对主动脉 ACE-2 没有抑制作用。
本研究说明了 AECO 作为一种降压和血管舒张剂的有益作用。
