在大鼠中的降压作用。
Antihypertensive Effect of in Rats.
机构信息
Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Errachidia, Morocco. BP 509 Errachidia, Morocco.
Team EMDD, Center of CERNE2D, Ecole Supérieure de Technologie, Boulevard Mohamed VI Salé, Université Mohammed V, Rabat, Morocco.
出版信息
Cardiovasc Hematol Agents Med Chem. 2023;21(3):213-222. doi: 10.2174/1871525721666230118154023.
AIMS
The study aimed to investigate the effect of on blood pressure.
BACKGROUND
is a medicinal plant with several medicinal properties.
OBJECTIVE
This study aimed to study the vasorelaxant and antihypertensive capacity of the aqueous extract of (E. cheiradenia), and to evaluate its effect on angiotensinconverting enzyme 2 (ACE2).
METHODS
The antihypertensive ability of aerial parts of the aqueous extract of E. cheiradenia (AEEC) was investigated in L-NAME-induced hypertensive rats, and its vasorelaxant effect was performed on the isolated thoracic rat aorta. In addition, the possible inhibitory effect of AEEC on ACE2 was also studied.
RESULTS
AEEC lowered blood pressure parameters in hypertensive rats. The study of the vasorelaxant activity revealed that AEEC partially relaxed the aortic rings through activation of the KATP channel and inhibition of the β-adrenergic pathway. Whereas pretreatment of aortic rings with nifedipine, indomethacin, L-NAME, and methylene blue did not attenuate AEEC-induced vasorelaxation. However, AEEC did not affect ACE2 in isolated rat aortas.
CONCLUSION
The study showed that aqueous E. cheiradenia extract exhibits significant antihypertensive activity in hypertensive rats.
目的
本研究旨在探讨[药物名称]对血压的影响。
背景
[植物名称]是一种具有多种药用特性的药用植物。
目的
本研究旨在研究[植物名称]（E. cheiradenia）水提物的血管舒张和降压作用，并评估其对血管紧张素转换酶 2（ACE2）的影响。
方法
在 L-NAME 诱导的高血压大鼠中研究了[植物名称]地上部分水提物（AEEC）的降压能力，并在离体大鼠胸主动脉上进行了其血管舒张作用的研究。此外，还研究了 AEEC 对 ACE2 可能的抑制作用。
结果
AEEC 降低了高血压大鼠的血压参数。血管舒张活性研究表明，AEEC 通过激活 KATP 通道和抑制β-肾上腺素能途径部分松弛主动脉环。然而，用硝苯地平、吲哚美辛、L-NAME 和亚甲蓝预处理主动脉环不能减弱 AEEC 诱导的血管舒张作用。然而，AEEC 对离体大鼠主动脉中的 ACE2 没有影响。
结论
本研究表明，[植物名称]水提物在高血压大鼠中表现出显著的降压活性。
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