Zhang JinFang, Zong Sa, Liao Bing
Department of Paediatric Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
SAGE Open Med Case Rep. 2022 Feb 24;10:2050313X221080328. doi: 10.1177/2050313X221080328. eCollection 2022.
The sequential occurrence of Langerhans cell histiocytosis and acute leukemia in only one individual has been reported previously; however, it is rarely observed that Langerhans cell histiocytosis can transform into acute lymphoblastic leukemia, and the underlying mechanisms remain unclear. In this report, we have analyzed a case of acute lymphoblastic leukemia converted from Langerhans cell histiocytosis using high-throughput sequencing method, and found that mitogen-activated protein kinase gene mutation, which can act as a marker for poor prognosis, might be involved in disease transformation. This is the first description about acute lymphoblastic leukemia B-cell type after Langerhans cell histiocytosis diagnosis and therapy in China.
此前曾有报道仅1例个体先后发生朗格汉斯细胞组织细胞增多症和急性白血病；然而，朗格汉斯细胞组织细胞增多症转化为急性淋巴细胞白血病的情况鲜有观察到，其潜在机制仍不清楚。在本报告中，我们使用高通量测序方法分析了1例由朗格汉斯细胞组织细胞增多症转化而来的急性淋巴细胞白血病病例，发现有丝分裂原激活蛋白激酶基因突变可能参与了疾病转化，该突变可作为预后不良的标志物。这是国内关于朗格汉斯细胞组织细胞增多症诊断和治疗后发生B细胞型急性淋巴细胞白血病的首次报道。
