Chen Charles B, Barry Jessica, Conjeevaram Selvakumar Praveen K, Hong Sandra, Mahajan Lori, Worley Sarah, Patel Sophia A
Pediatric Gastroenterology, University of Missouri, Columbia, USA.
Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, Cleveland, USA.
Cureus. 2022 Jan 27;14(1):e21675. doi: 10.7759/cureus.21675. eCollection 2022 Jan.
Eosinophilic esophagitis is a chronic, immune-mediated esophageal condition that may lead to impairment of quality of life in pediatric and young adult patients. We performed a prospective, cross-sectional study on 40 patients between the ages of 2-21 years with an established diagnosis of eosinophilic esophagitis. The study evaluated physical, emotional, social, and school functioning in patients undergoing treatment with proton pump inhibitors, dietary elimination, or swallowed corticosteroids. There were no statistically significant differences in total or domain-specific quality of life scores between proton pump inhibitors, dietary elimination, and swallowed corticosteroid therapy. Overall, total and domain-specific quality of life were well-preserved in patients with eosinophilic esophagitis, with the highest scores reported in social functioning. There were also no statistically significant associations between clinical, endoscopic, and histologic features and quality-of-life measures.
嗜酸性粒细胞性食管炎是一种慢性的、免疫介导的食管疾病，可能会导致儿童和年轻成年患者的生活质量受损。我们对40名年龄在2至21岁之间、已确诊为嗜酸性粒细胞性食管炎的患者进行了一项前瞻性横断面研究。该研究评估了接受质子泵抑制剂、饮食排除或吞咽皮质类固醇治疗的患者的身体、情绪、社交和学校功能。质子泵抑制剂、饮食排除和吞咽皮质类固醇治疗之间的总体或特定领域生活质量评分没有统计学上的显著差异。总体而言，嗜酸性粒细胞性食管炎患者的总体和特定领域生活质量得到了很好的保留，社交功能得分最高。临床、内镜和组织学特征与生活质量指标之间也没有统计学上的显著关联。
