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骨骼肌线粒体产生的线粒体 ROS 促进 UPＲmt 激活的决定性信号。

Mitochondrial ROS Produced by Skeletal Muscle Mitochondria Promote the Decisive Signal for UPRmt Activation.

机构信息

Tianjin University of Sport, Tianjin Key Laboratory of Exercise, Physiology and Sports Medicine, Research Center for Exercise & Health Science, Tianjin 301617, China.

Department of Military Training Medicines, Logistics University of Chinese People's Armed Police Force, Tianjin 300162, China.

出版信息

Biomed Res Int. 2022 Feb 21;2022:7436577. doi: 10.1155/2022/7436577. eCollection 2022.

DOI:10.1155/2022/7436577
PMID:35237690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8885241/
Abstract

The itochondrial unfolded protein response (UPRmt) can repair and remove misfolded or unfolded proteins in mitochondria and enhance mitochondrial protein homeostasis. Reactive oxygen species (ROS) produced by regular exercise is a crucial signal for promoting health, and skeletal muscle mitochondria are the primary source of ROS during exercise. To verify whether UPRmt is related to ROS produced by mitochondria in skeletal muscle during regular exercise, we adapted MitoTEMPO, mitochondrially targeted antioxidants, and ROS production by mitochondria. Our results showed that itochondrial ROS is the key factor for activating UPRmt in different pathways.

摘要

线粒体未折叠蛋白反应 (UPRmt) 可以修复和清除线粒体中错误折叠或未折叠的蛋白质，并增强线粒体蛋白质的动态平衡。有规律的运动所产生的活性氧 (ROS) 是促进健康的关键信号，而运动过程中骨骼肌线粒体是 ROS 的主要来源。为了验证 UPRmt 是否与有规律的运动过程中骨骼肌线粒体产生的 ROS 有关，我们采用了线粒体靶向抗氧化剂 MitoTEMPO 和线粒体产生的 ROS。我们的结果表明，线粒体 ROS 是激活不同途径 UPRmt 的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/c1593d8ca9b3/BMRI2022-7436577.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/e1e17ac7803b/BMRI2022-7436577.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/5a75672872c8/BMRI2022-7436577.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/7aa0ec13a9a5/BMRI2022-7436577.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/80186a8167b1/BMRI2022-7436577.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/c1593d8ca9b3/BMRI2022-7436577.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/e1e17ac7803b/BMRI2022-7436577.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/5a75672872c8/BMRI2022-7436577.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/7aa0ec13a9a5/BMRI2022-7436577.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/80186a8167b1/BMRI2022-7436577.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eae2/8885241/c1593d8ca9b3/BMRI2022-7436577.004.jpg

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