慢性地西泮治疗期间地西泮和去甲地西泮的血浆浓度
Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.
作者信息
Rutherford D M, Okoko A, Tyrer P J
出版信息
Br J Clin Pharmacol. 1978 Jul;6(1):69-73. doi: 10.1111/j.1365-2125.1978.tb01684.x.
Abstract
1 Plasma concentrations of diazepam and its metabolite, desmethyldiazepam, have been measured in both in- and out-patient groups treated with diazepam for periods varying between 1 month and 10 years. 2 The diazepam concentration was directly related to the dose of diazepam ingested and inversely related to the age of the patient. 3 A highly significant relationship was obtained between the concentration of desmethyldiazepam and diazepam. 4 The plasma concentrations of both diazepam and its metabolite were independent of sex, duration fo therapy and patient group.
摘要
- 已对使用地西泮治疗1个月至10年不等的门诊和住院患者组测定了地西泮及其代谢产物去甲基地西泮的血浆浓度。2. 地西泮浓度与摄入的地西泮剂量直接相关，与患者年龄呈负相关。3. 去甲基地西泮浓度与地西泮之间存在高度显著的关系。4. 地西泮及其代谢产物的血浆浓度与性别、治疗持续时间和患者组无关。
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