苯二氮䓬类药物的血浆浓度。
Plasma concentrations of benzodiazepines.
作者信息
Bond A J, Hailey D M, Lader M H
出版信息
Br J Clin Pharmacol. 1977 Feb;4(1):51-6. doi: 10.1111/j.1365-2125.1977.tb00666.x.
Abstract
- Twenty anxious patients were treated with medazepam, diazepam, chlordiazepoxide, amylobarbitone and placebo, each given in flexible dosage for 2-4 weeks. 2. At the end of each treatment, a series of clinical, physiological and behavioural variables were measured and plasma samples were taken for estimation of the appropriate drug and metabolite concentrations. 3. Nordiazepam was shown to be an important metabolite of both medazepam and diazepam: the ratio of medazepam to noradiazepam was 0.14 and the ratio of diazepam to nordiazepam following diazepam administration was 0.72. 4. No significant correlations were found between the plasma concentrations of any of the treatments and the clinical ratings or behavioural measures. 5. Some relationship was shown between levels of medazepam and its physiological effects.
摘要
- 20名焦虑症患者接受了美达西泮、地西泮、氯氮卓、戊巴比妥和安慰剂治疗，每种药物采用灵活剂量给药，持续2至4周。2. 在每次治疗结束时，测量一系列临床、生理和行为变量，并采集血浆样本以测定相应药物和代谢物浓度。3. 去甲西泮被证明是美达西泮和地西泮的重要代谢物：美达西泮与去甲西泮的比例为0.14，地西泮给药后地西泮与去甲西泮的比例为0.72。4. 未发现任何治疗的血浆浓度与临床评分或行为测量之间存在显著相关性。5. 美达西泮水平与其生理效应之间存在一定关系。
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