Plasma concentrations of benzodiazepines.
作者信息
Bond A J, Hailey D M, Lader M H
出版信息
Br J Clin Pharmacol. 1977 Feb;4(1):51-6. doi: 10.1111/j.1365-2125.1977.tb00666.x.
Abstract
- Twenty anxious patients were treated with medazepam, diazepam, chlordiazepoxide, amylobarbitone and placebo, each given in flexible dosage for 2-4 weeks. 2. At the end of each treatment, a series of clinical, physiological and behavioural variables were measured and plasma samples were taken for estimation of the appropriate drug and metabolite concentrations. 3. Nordiazepam was shown to be an important metabolite of both medazepam and diazepam: the ratio of medazepam to noradiazepam was 0.14 and the ratio of diazepam to nordiazepam following diazepam administration was 0.72. 4. No significant correlations were found between the plasma concentrations of any of the treatments and the clinical ratings or behavioural measures. 5. Some relationship was shown between levels of medazepam and its physiological effects.
摘要
相似文献
1
Plasma concentrations of benzodiazepines.
Br J Clin Pharmacol. 1977 Feb;4(1):51-6. doi: 10.1111/j.1365-2125.1977.tb00666.x.
2
Plasma concentrations of diazepam, noradiazepam and amylobarbitone after short-term treatment of anxious patients.
Pharmakopsychiatr Neuropsychopharmakol. 1978 Mar;11(2):68-75. doi: 10.1055/s-0028-1094564.
3
Plasma concentrations of medazepam and its metabolites after oral administration.
Br J Anaesth. 1979 Jun;51(6):493-6. doi: 10.1093/bja/51.6.493.
4
Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam.
Ann Clin Res. 1977 Oct;9(5):284-6.
5
Analysis of medazepam, diazepam, and metabolites in plasma by gas-liquid chromatography with electrolytic conductivity detection.
J Chromatogr. 1977 Jun 1;136(1):127-39. doi: 10.1016/s0021-9673(00)83001-0.
6
7
Determination of chlordiazepoxide, diazepam, and their major metabolites in blood or plasma by spectrophotodensitometry.
J Chromatogr. 1977 Jul 1;143(4):363-74. doi: 10.1016/s0378-4347(00)80982-2.
8
Sedative effects on physiological and psychological measures in anxious patients.
Psychol Med. 1974 Nov;4(4):374-80. doi: 10.1017/s0033291700045815.
9
Introduction to the pharmacokinetics and pharmacodynamics of benzodiazepines.
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):623-7. doi: 10.1016/0278-5846(83)90035-0.
10
Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.
Toxicol Lett. 2010 Mar 15;193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. Epub 2010 Jan 18.
引用本文的文献
1
Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA receptor: In vitro and in vivo studies.
Br J Pharmacol. 2021 Dec;178(24):4842-4858. doi: 10.1111/bph.15662. Epub 2021 Sep 26.
2
Flavonoid modulation of GABA(A) receptors.
Br J Pharmacol. 2011 May;163(2):234-45. doi: 10.1111/j.1476-5381.2011.01228.x.
3
Pharmacokinetic-pharmacodynamic relationships for benzodiazepines.
Clin Pharmacokinet. 1996 Jan;30(1):52-76. doi: 10.2165/00003088-199630010-00004.
4
Diazepam withdrawal syndrome: its prolonged and changing nature.
Can Med Assoc J. 1982 Dec 1;127(11):1093-6.
5
The relationships between clinical response, psychophysiological variables and plasma levels of amitriptyline and diazepam in neurotic outpatients.
Psychopharmacology (Berl). 1981;72(3):233-40. doi: 10.1007/BF00431822.
6
Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy.
Br J Clin Pharmacol. 1981 Jan;11(1):35-40. doi: 10.1111/j.1365-2125.1981.tb01099.x.
7
RO5-4864, a ligand for benzodiazepine micromolar and peripheral binding sites: antagonism and enhancement of behavioural effects.
Psychopharmacology (Berl). 1983;80(2):166-70. doi: 10.1007/BF00427962.
8
Benzodiazepines impair smooth pursuit eye movements.
Br J Clin Pharmacol. 1983 Feb;15(2):259-62. doi: 10.1111/j.1365-2125.1983.tb01495.x.
9
A radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites.
Br J Clin Pharmacol. 1982 Apr;13(4):561-5. doi: 10.1111/j.1365-2125.1982.tb01422.x.
10
Benzodiazepines: clinical pharmacology and therapeutic use.
Drugs. 1980 Mar;19(3):195-219. doi: 10.2165/00003495-198019030-00004.
本文引用的文献
1
Determination of medazepam (nobrium), diazepam(valium) and their major biotransformation products in blod and urine by electron capture s-liquid chromatography.
Anal Chem. 1970 Dec;42(14):1725-36. doi: 10.1021/ac50160a040.
2
Pharmacokinetics of diazepam in dogs, mice and humans.
Acta Pharmacol Toxicol (Copenh). 1971;29 Suppl 3:109-27. doi: 10.1111/j.1600-0773.1971.tb03291.x.
3
Physiologic and clinical effects of chlorpromazine and their relationship to plasma level.
Clin Pharmacol Ther. 1972 Nov-Dec;13(6):931-46. doi: 10.1002/cpt1972136931.
4
Determination of bioavailability of diazepam in various formulations from steady state plasma concentration data.
Clin Pharmacol Ther. 1972 Sep-Oct;13(5):733-44. doi: 10.1002/cpt1972135part1733.
5
Residual effects of hypnotics.
Psychopharmacologia. 1972;25(2):117-32. doi: 10.1007/BF00423189.
6
Concentration-effect relationships with major and minor tranquilizers.
Clin Pharmacol Ther. 1974 Jul;16(1):192-7. doi: 10.1002/cpt1974161part2192.
7
Plasma concentrations of diazepam and of its metabolite N-desmethyldiazepam in relation to anxiolytic effect.
Clin Pharmacol Ther. 1974 May;15(5):473-83. doi: 10.1002/cpt1974155473.
8
Gas chromatographic analysis of the commonly prescribed barbiturates at therapeutic and overdose levels in plasma and urine.
J Chromatogr. 1973 Nov 7;86(1):89-105. doi: 10.1016/s0021-9673(01)81238-3.
9
A gas chromatographic assay for medazepam and its major metabolites in plasma.
Clin Chim Acta. 1973 Sep 28;48(1):105-8. doi: 10.1016/0009-8981(73)90223-4.
10
[Analysis of benzodiazepines using gas chromatography, 1. Medazepam and its metabolites].
Arzneimittelforschung. 1973 Apr;23(4):614-6.
Zotero 插件