Department of Internal Medicine, St. Marianna University School of Medicine, Division of General Internal Medicine, Kawasaki, Kanagawa, Japan.
Department of Infectious Diseases, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
J Med Virol. 2022 Jul;94(7):3416-3420. doi: 10.1002/jmv.27689. Epub 2022 Mar 8.
Coronavirus disease 2019 (COVID-19) is spreading worldwide; there is a need to address its sequelae known as Long COVID. This study evaluated postvaccination changes in symptoms and antibody titers in patients with Long COVID. Patients visiting the outpatient department specializing in Long COVID at our hospital were enrolled. Changes in symptoms were evaluated before and 14-21 days after first vaccination. Antibody titers were measured using ARCHITECT SARS-CoV-2 IgG II Quant at the same time. This study included 42 patients (median age: 45 years; 17 [40.5%] men). Median pre- and postvaccination antibody titers were 456 and 28,963 AU/ml, respectively. Postvaccination symptoms (fatigue, joint pain, and taste and olfactory abnormalities) were relieved, worsened, and unchanged in 7 (16.7%), 9 (21.4%), and 26 (61.9%) patients, respectively. Ratios of pre- and postvaccination antibody titers were 53, 40, and 174 in the unchanged, relief, and worsened groups, respectively. The worsened group had the significantly highest antibody titer ratio (p = 0.02). The higher increased rate of the antibody titer in the worsened group than in the nonworsened group suggests an excessive immune response to vaccination associated with worsening of sequelae. Although patients with Long COVID should be vaccinated, additional concerns should be addressed.
新型冠状病毒疾病 2019（COVID-19）在全球范围内传播；需要解决被称为长新冠的后遗症。本研究评估了长新冠患者接种疫苗后症状和抗体滴度的变化。在我们医院专门治疗长新冠的门诊部就诊的患者被纳入研究。在首次接种疫苗前和 14-21 天后评估症状变化。同时使用 ARCHITECT SARS-CoV-2 IgG II Quant 测量抗体滴度。本研究纳入 42 名患者（中位年龄：45 岁；17 [40.5%]名男性）。中位接种前和接种后抗体滴度分别为 456 和 28963 AU/ml。接种后症状（疲劳、关节痛、味觉和嗅觉异常）在 7 名（16.7%）、9 名（21.4%）和 26 名（61.9%）患者中分别得到缓解、恶化和无变化。不变、缓解和恶化组的预接种和接种后抗体滴度比值分别为 53、40 和 174。恶化组的抗体滴度比值显著最高（p=0.02）。恶化组的抗体滴度增加率明显高于非恶化组，提示与后遗症恶化相关的疫苗接种后过度免疫反应。尽管长新冠患者应该接种疫苗，但应注意其他问题。
