MMWR Morb Mortal Wkly Rep. 2021 Aug 13;70(32):1081-1083. doi: 10.15585/mmwr.mm7032e1.
Although laboratory evidence suggests that antibody responses following COVID-19 vaccination provide better neutralization of some circulating variants than does natural infection (1,2), few real-world epidemiologic studies exist to support the benefit of vaccination for previously infected persons. This report details the findings of a case-control evaluation of the association between vaccination and SARS-CoV-2 reinfection in Kentucky during May-June 2021 among persons previously infected with SARS-CoV-2 in 2020. Kentucky residents who were not vaccinated had 2.34 times the odds of reinfection compared with those who were fully vaccinated (odds ratio [OR] = 2.34; 95% confidence interval [CI] = 1.58-3.47). These findings suggest that among persons with previous SARS-CoV-2 infection, full vaccination provides additional protection against reinfection. To reduce their risk of infection, all eligible persons should be offered vaccination, even if they have been previously infected with SARS-CoV-2.
虽然实验室证据表明,与自然感染相比,COVID-19 疫苗接种后的抗体反应能更好地中和一些流行变异株(1,2),但很少有真实世界的流行病学研究支持疫苗接种对既往感染者的益处。本报告详细介绍了 2021 年 5 月至 6 月期间,肯塔基州对既往感染过 SARS-CoV-2 的人群中,疫苗接种与 SARS-CoV-2 再感染之间关联的病例对照评估结果。与完全接种疫苗者相比,未接种疫苗的肯塔基州居民再感染的几率高 2.34 倍(比值比[OR] = 2.34;95%置信区间[CI] = 1.58-3.47)。这些发现表明,对于既往感染过 SARS-CoV-2 的人群,完全接种疫苗可提供针对再感染的额外保护。为了降低感染风险,所有符合条件的人都应接种疫苗,即使他们曾感染过 SARS-CoV-2。