Schlesinger Naomi, Elsaid Mohamed I, Rustgi Vinod K
Division of Rheumatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Clin Exp Rheumatol. 2022 Mar;40(3):631-633. doi: 10.55563/clinexprheumatol/2rn9fv. Epub 2022 Feb 1.
To examine Metabolic Syndrome (MetS) severity using a recently validated Metabolic Syndrome Severity Score (MetSSS) in order to explore the overall associations between MetSSS and the risk of mortality related to all-causes, heart disease, diabetes mellitus, and hypertension amongst American adults with gout.
Mortality-linked data for 12,101 adults aged 18 to 90 years who participated in the National Health and Nutrition Examination Survey III by gout status was analysed. All 5 metabolic features were used to calculate gender-race/ethnicity-specific MetSSS Z-scores in gout patients. The calculated Z-scores are a continuous representation of all MetS conditions while accounting for gender-race/ethnicity disparities.
A total of 3,381 deaths were observed, of which 215 had gout. The prevalence amongst adults was 2.59%. Moderate to high MetS severity was significantly prevalent amongst gout patients (47.33% vs. 21.16 % no gout; p-value <0.0001). The mean MetSSS Zscore for gout patients was significantly higher than those without gout (0.71 vs. -0.04 no gout; p-value <0.0001). A one-unit increase in MetSSS score was associated with significant increases in the risk of all-cause mortality, heart disease, diabetes- and hypertension-related mortalities.
Moderate to high MetSSS is significantly prevalent amongst gout patients. A one-unit increase in MetSSS score was associated with significant increases in the risk of all-cause mortality, heart disease, diabetes- and hypertension-related mortalities. MetS is a clinically accessible tool for predicting mortality risks in gout patients with MetS.
使用最近验证的代谢综合征严重程度评分（MetSSS）来检查代谢综合征（MetS）的严重程度，以探讨MetSSS与美国痛风成年患者全因、心脏病、糖尿病和高血压相关死亡风险之间的总体关联。
分析了12101名年龄在18至90岁之间、根据痛风状况参与第三次全国健康和营养检查调查的成年人的死亡相关数据。使用所有5种代谢特征来计算痛风患者特定性别-种族/族裔的MetSSS Z评分。计算出的Z评分是所有MetS状况的连续表示，同时考虑了性别-种族/族裔差异。
共观察到3381例死亡，其中215例患有痛风。成年人中的患病率为2.59%。中度至高度MetS严重程度在痛风患者中显著普遍（47.33%对无痛风者的21.16%；p值<0.0001）。痛风患者的平均MetSSS Z评分显著高于无痛风者（0.71对无痛风者的-0.04；p值<0.0001）。MetSSS评分每增加一个单位，与全因死亡率、心脏病、糖尿病和高血压相关死亡率的风险显著增加相关。
中度至高度MetSSS在痛风患者中显著普遍。MetSSS评分每增加一个单位，与全因死亡率、心脏病、糖尿病和高血压相关死亡率的风险显著增加相关。MetS是预测患有MetS的痛风患者死亡风险的一种临床可用工具。
