Belviranlı Muaz, Okudan Nilsel, Sezer Tuğba
School of Medicine, Department of Physiology, Selçuk University, Konya, 42131, Turkey.
Metab Brain Dis. 2025 Apr 10;40(4):174. doi: 10.1007/s11011-025-01602-0.
The neurodegenerative condition known as Parkinson's disease (PD) is a long-term condition that causes both motor and non-motor symptoms. It is known that curcumin has a strong neuroprotective potential. This experimental study was designed to examine the anti-inflammatory, anti-apoptotic and neuroprotective effects of curcumin administered alone and in combination with L-DOPA in the hippocampus as well as behavioral symptoms in rotenone-induced PD model. Forty-two 4-month-old adult male Wistar rats were randomly divided into six groups as follows: Control, Curcumin, Rotenone, Rotenone plus curcumin, Rotenone plus L-DOPA and Rotenone plus curcumin plus L-DOPA. Control group received vehicles, curcumin group received curcumin (200 mg kg, daily for 35 days), rotenone group received rotenone (2 mg kg, daily for 35 days), and test groups received curcumin or L-DOPA (10 mg kg, daily for the last 15 days) or their combination in addition the rotenone. Pole, sucrose preference, open field, elevated plus maze, and Morris water maze tests were performed after treatment. Molecular and biochemical analyses were performed in the hippocampus tissue and serum samples. Rotenone injection caused impairments in motor activity, depressive-like behavior, and learning and memory functions. Rotenone also increased the expressions of α-synuclein, caspase 3, NF-κB, and decreased the expressions of parkin and BDNF in the hippocampus. However, especially curcumin and L-DOPA combined treatment normalized all these impaired molecular and behavioral variables. In conclusion, curcumin may exert beneficial effects in treatment strategies for PD-related hippocampal effects, especially when added to L-DOPA therapy.
被称为帕金森病（PD）的神经退行性疾病是一种导致运动和非运动症状的长期病症。已知姜黄素具有很强的神经保护潜力。本实验研究旨在检查单独给予姜黄素以及姜黄素与左旋多巴联合给药在海马体中的抗炎、抗凋亡和神经保护作用，以及在鱼藤酮诱导的帕金森病模型中的行为症状。将42只4个月大的成年雄性Wistar大鼠随机分为六组，如下：对照组、姜黄素组、鱼藤酮组、鱼藤酮加姜黄素组、鱼藤酮加左旋多巴组和鱼藤酮加姜黄素加左旋多巴组。对照组给予赋形剂，姜黄素组给予姜黄素（200毫克/千克，每日一次，共35天），鱼藤酮组给予鱼藤酮（2毫克/千克，每日一次，共35天），试验组除鱼藤酮外还给予姜黄素或左旋多巴（10毫克/千克，在最后15天每日一次）或它们的组合。治疗后进行杆试验、蔗糖偏好试验、旷场试验、高架十字迷宫试验和莫里斯水迷宫试验。在海马组织和血清样本中进行分子和生化分析。注射鱼藤酮导致运动活动、抑郁样行为以及学习和记忆功能受损。鱼藤酮还增加了海马体中α-突触核蛋白、半胱天冬酶3、核因子κB的表达，并降低了帕金森蛋白和脑源性神经营养因子的表达。然而，尤其是姜黄素和左旋多巴联合治疗使所有这些受损的分子和行为变量恢复正常。总之，姜黄素可能在帕金森病相关海马体效应的治疗策略中发挥有益作用，特别是在添加到左旋多巴治疗中时。
