Department of Otolaryngology, University of Brasilia, Brazil.
Int Tinnitus J. 2022 Mar 3;25(2):149-153. doi: 10.5935/0946-5448.20210027.
Tinnitus is a frequent complaint in otorhinolaryngology. The symptoms of tinnitus those are severe enough to significantly affect the quality of life. Numerous therapeutic interventions and studies claim success in the treatment of tinnitus, but the cure remains undefined. However, ozone therapy has been suggested as potential treatment for tinnitus.
This systematic review aims to investigate the efficacy of ozone therapy in the treatment of tinnitus.
A systematic search was performed in MEDLINE, Web of Science, Cochrane Library, Science Direct, Scopus, Google Scholar, Embase and LILACS. Data was processed by two independent reviewers. Only Systematic Reviews, Randomized Controlled Trials, Observational Studies and Case Series published in English or Spanish with no date limit that evaluated the use of ozone therapy for the treatment of tinnitus were included.
From 264 references retrieved after duplicates removal, 260 articles were excluded according to the pre-established selection criteria. The assessed articles were then subjected to risk of bias analysis, and one of them was excluded.
High-level evidence, such as well-conducted randomized clinical trials, are still needed to confirm the efficacy and safety of this therapy.
耳鸣是耳鼻喉科常见的主诉。耳鸣症状严重到足以显著影响生活质量。许多治疗干预措施和研究声称对耳鸣的治疗有效，但治愈仍未定义。然而，臭氧疗法已被提议作为耳鸣的潜在治疗方法。
本系统评价旨在调查臭氧疗法治疗耳鸣的疗效。
在 MEDLINE、Web of Science、Cochrane 图书馆、Science Direct、Scopus、Google Scholar、Embase 和 LILACS 中进行了系统搜索。数据由两名独立评审员处理。仅包括发表在英语或西班牙语、无时间限制、评估臭氧疗法治疗耳鸣的系统评价、随机对照试验、观察性研究和病例系列研究。
在去除重复项后检索到的 264 篇参考文献中，根据预先确定的选择标准排除了 260 篇文章。然后对评估的文章进行偏倚风险分析，并排除了其中一篇。
仍需要进行设计良好的随机临床试验等高质量证据来证实这种疗法的疗效和安全性。
