Brazilian Society of Medical Ozone Therapy (SOBOM), São Paulo, Brazil.
World Federation of Ozone Therapy (WFOT), Brescia, Italy.
Front Public Health. 2023 Jan 16;10:1112296. doi: 10.3389/fpubh.2022.1112296. eCollection 2022.
The Brazil has one of the largest public health systems in the world and in the 1980's, Traditional, Complementary and Integrative Medicine were introduced. In 2018, the treatment with ozone became a complementary integrative practice showing several benefits. However, its effectiveness needs to be researched. The objective of this evidence gap map is to describe contributions of Integrative Medicines-Ozone treatment in different clinical conditions, to promote evidence-based practice.
We applied the methodology developed by Latin American and Caribbean Center on Health Sciences Information based on the 3iE evidence gap map. The EMBASE, PubMed and Virtual Health Library databases, using the MeSH and DeCS terms for the treatment with Ozone were used.
26 systematic reviews were characterized, distributed in a matrix containing 6 interventions (parenteral oxygen/ozone gas mixture; parenteral ozonated water; systemic routes; topical application ozonated water; topical oxygen/ozone gas mixture; and topical ozonated oil) and 55 outcomes (cancer, infection, inflammation, pain, quality of life, wound healing and adverse effects). 334 associations between intervention and outcome were observed, emphasizing the parenteral oxygen/ozone gas mixture intervention (192 associations, 57%).
The evidence gap map presents an overview of contributions of Ozone treatment in controlling pain, infections, inflammation and wound healing, as well as increasing the quality of life, and it is directed to researchers and health professionals specialized in Ozone treatment. No serious adverse effects were related. Therefore, this treatment may be even more widely known as an integrative treatment, considering its low cost, efficiency and safety. Future studies should adopt economic impact assessments and the organization of health services.
巴西拥有世界上最大的公共卫生系统之一，20 世纪 80 年代引入了传统医学、补充医学和整合医学。2018 年，臭氧治疗成为一种补充整合实践，显示出多种益处。然而，其疗效仍需研究。本证据差距图的目的是描述不同临床情况下整合医学-臭氧治疗的贡献，以促进循证实践。
我们应用了基于拉丁美洲和加勒比卫生科学信息中心的 3iE 证据差距图方法学。使用 EMBASE、PubMed 和虚拟健康图书馆数据库，使用臭氧治疗的 MeSH 和 DeCS 术语。
共描述了 26 项系统评价，分布在一个包含 6 项干预措施（静脉内氧气/臭氧混合气体；静脉内臭氧水；全身途径；局部应用臭氧水；局部氧气/臭氧混合气体；局部臭氧油）和 55 项结局（癌症、感染、炎症、疼痛、生活质量、伤口愈合和不良反应）的矩阵中。观察到干预措施和结局之间有 334 种关联，强调了静脉内氧气/臭氧混合气体干预措施（192 种关联，57%）。
证据差距图概述了臭氧治疗在控制疼痛、感染、炎症和伤口愈合、提高生活质量方面的贡献，针对臭氧治疗的研究人员和卫生专业人员。没有发现严重的不良反应。因此，这种治疗方法可能会因为其低成本、高效率和安全性而被更广泛地认为是一种整合治疗方法。未来的研究应采用经济影响评估和卫生服务组织。
