Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Department of Public Health and Research, West African Health Organization, Bobo-Dioulasso, Burkina Faso.
PLoS One. 2022 Mar 3;17(3):e0264728. doi: 10.1371/journal.pone.0264728. eCollection 2022.
As high blood pressure (HBP) is often considered an adult disease in Africa, studies on and services for HBP focus on adults to the near-exclusion of adolescents. The dearth of information about the burden of HBP does not favour much attention being paid to it. We, therefore, prepared this protocol to estimate the prevalence and awareness of HBP in adolescents in Africa through a systematic review and meta-analysis.
We will search several major databases for published and unpublished articles on population-based studies on adolescents living in Africa, aged 10-19 years produced from the year 2000 to date. The included articles will be those that define HBP according to international guidelines using the blood pressure cut-offs of the 95th percentile for age, sex and height or of 130/90 mmHg, depending on the age of the subjects. The study selection as well as the evaluation of the quality of the included articles will be done independently by two reviewers, in line with best practices. We will pool together the prevalence across studies using random effects analysis and assess heterogeneity using meta-regression analysis and sub-group analysis. Sensitivity analysis using a leave-one-out analysis and an evaluation of reporting bias will also be performed. Reporting of our findings will conform to the recommended reporting guidelines.
The findings from our comprehensive systematic review and meta-analysis will provide an up-to-date information on the prevalence of HBP and its awareness among adolescents in Africa and its sub-regions. They could be used to advocate for increased priority to life course approach to the prevention of cardiovascular diseases.
PROSPERO CRD42020197946.
在非洲，高血压（HBP）通常被认为是一种成人疾病，因此针对 HBP 的研究和服务主要针对成年人，几乎完全忽略了青少年。由于缺乏关于 HBP 负担的信息，因此对其关注甚少。因此，我们制定了本方案，通过系统评价和荟萃分析来估计非洲青少年中 HBP 的患病率和知晓率。
我们将在几个主要数据库中搜索有关 2000 年至今在非洲生活的 10-19 岁青少年的基于人群的研究的已发表和未发表的文章。纳入的文章将是根据国际指南，使用年龄、性别和身高第 95 百分位的血压切点或 130/90mmHg 定义 HBP 的文章，具体取决于研究对象的年龄。研究选择以及纳入文章的质量评估将由两位评审员独立进行，符合最佳实践。我们将使用随机效应分析汇总研究间的患病率，并使用荟萃回归分析和亚组分析评估异质性。还将进行敏感性分析（使用删去一个的分析）和报告偏倚评估。我们的报告将符合推荐的报告指南。
我们全面的系统评价和荟萃分析的结果将提供有关非洲及其次区域青少年 HBP 患病率及其知晓率的最新信息。这些信息可用于倡导增加对预防心血管疾病的生命历程方法的重视。
PROSPERO CRD42020197946。
