生殖质与线虫生殖系中的基因调控。
Germ granules and gene regulation in the Caenorhabditis elegans germline.
机构信息
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
The Mount Desert Island Biological Laboratory, Bar Harbor, ME 04672, USA.
出版信息
Genetics. 2022 Mar 3;220(3). doi: 10.1093/genetics/iyab195.
Abstract
The transparency of Caenorhabditis elegans provides a unique window to observe and study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) assemblies specific to the germline cytoplasm, and they are largely conserved across Metazoa. Within the germline cytoplasm, they are positioned to regulate mRNA abundance, translation, small RNA production, and cytoplasmic inheritance to help specify and maintain germline identity across generations. Here we provide an overview of germ granules and focus on the significance of more recent observations that describe how they further demix into sub-granules, each with unique compositions and functions.
摘要
秀丽隐杆线虫的透明性为观察和研究生殖细胞颗粒的功能提供了一个独特的窗口。生殖细胞颗粒是专门的核糖核蛋白（RNP）组装体，特异性存在于生殖细胞质中，在后生动物中广泛保守。在生殖细胞质中，它们的位置可以调节 mRNA 的丰度、翻译、小 RNA 的产生和细胞质的遗传，以帮助在代际间指定和维持生殖细胞的身份。本文概述了生殖细胞颗粒，并重点介绍了最近的一些观察结果的意义，这些结果描述了它们如何进一步分解为具有独特组成和功能的亚颗粒。
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