Joost J
Wien Klin Wochenschr. 1986 May 30;98(11):355-7.
28 patients with urinary tract infections (UTI) were treated with norfloxacin 2 X 400 mg daily for 9 days. 14 of these patients had complicated UTI (stones, obstruction). The main pathogens were E. coli and Proteus mirabilis. On the third day of treatment all bacteria were eradicated. One week after therapy all patients with uncomplicated UTI were cured and, likewise, 9 of 14 with complicated UTI. There was no laboratory evidence of adverse effects. 6 patients reported only mild side effects such as epigastric pain, dizziness and pruritus, which did not necessitate discontinuation of norfloxacin. Norfloxacin appears to be safe and effective in the treatment of UTI.
28例尿路感染患者接受诺氟沙星治疗，每日2次，每次400mg，疗程9天。其中14例患者患有复杂性尿路感染（结石、梗阻）。主要病原体为大肠杆菌和奇异变形杆菌。治疗第三天所有细菌均被根除。治疗一周后，所有非复杂性尿路感染患者均治愈，14例复杂性尿路感染患者中有9例治愈。无实验室证据表明有不良反应。6例患者仅报告有轻微副作用，如中上腹疼痛、头晕和瘙痒，无需停用诺氟沙星。诺氟沙星治疗尿路感染似乎安全有效。
