诺氟沙星治疗尿路感染的临床经验

[Clinical experience of norfloxacin in urinary tract infection].

作者信息

Banya Y, Funaki H, Takagane H, Tanji S, Abe T, Aoki H, Kubo T, Ohori T

出版信息

Hinyokika Kiyo. 1985 Aug;31(8):1501-17.

Abstract

Norfloxacin (NFLX) was administered to outpatients and inpatients with urinary tract infections at our department. Clinical efficacy and safety were evaluated in 50 patients by the criteria for evaluation of clinical efficacy of antimicrobial agents on urinary tract infection. Overall clinical efficacy for 17 cases with acute simple cystitis was excellent in 13 cases, moderate in 4 cases with an effectiveness rate of 100%. The overall clinical efficacy for 33 cases with chronic complicated UTI was excellent in 18 cases, moderate in 6 cases and poor in 9 cases with an effectiveness rate of 73%. The eradication rate of 21 strains from acute simple cystitis patients was 100%. Forty four out of 60 strains from chronic complicated UTI patients were eradicated and the eradication rate was 73%. Neither subjective nor objective adverse reactions were observed in 50 patients. Abnormal changes in laboratory tests were found in 8 patients, but were probably not related to NFLX administration. Judging from these results, NFLX is considered to be an effective and safe antibacterial for the treatment of UTI.

摘要

我院对门诊和住院的尿路感染患者使用诺氟沙星（NFLX）进行治疗。按照抗菌药物治疗尿路感染的临床疗效评价标准，对50例患者的临床疗效和安全性进行了评估。17例急性单纯性膀胱炎患者中，13例临床疗效极佳，4例疗效中等，有效率为100%。33例慢性复杂性尿路感染患者中，18例临床疗效极佳，6例疗效中等，9例疗效较差，有效率为73%。急性单纯性膀胱炎患者的21株病原菌清除率为100%。慢性复杂性尿路感染患者的60株病原菌中，44株被清除，清除率为73%。50例患者均未观察到主观或客观的不良反应。8例患者实验室检查出现异常变化，但可能与使用NFLX无关。从这些结果来看，NFLX被认为是治疗尿路感染安全有效的抗菌药物。