Behrendt Marc
Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13-17, D-68167 Mannheim, Germany.
Biol Chem. 2022 Mar 2;403(8-9):859-868. doi: 10.1515/hsz-2021-0403. Print 2022 Jul 26.
The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression patterns differ between species and change during development. Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified and the majority of these isoforms are yet to be characterized. Moreover, the mechanisms underlying regulation of TRPM3 are largely unexplored. In addition, a micro-RNA gene (miR-204) is located within the TRPM3 gene. This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics. However, a clear picture is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target. Therefore, the newest data related to TRPM3 have to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation from bench to bedside. The aim of this review is to highlight recent results and developments with particular focus on findings from studies involving ocular tissues and cells or peripheral neurons of rodents and humans.
钙通透阳离子通道TRPM3可被热和内源性类固醇硫酸孕烯醇酮激活。TRPM3最广为人知的功能是其在小鼠中作为外周有害热传感器的作用。然而，该通道在包括神经元以及神经胶质细胞和上皮细胞在内的各种组织和细胞类型中均有表达。TRPM3的表达模式在不同物种之间存在差异，并且在发育过程中会发生变化。此外，已经鉴定出大量由可变剪接产生的TRPM3变体，其中大多数异构体尚未得到表征。而且，TRPM3调控的潜在机制在很大程度上尚未被探索。另外，一个微小RNA基因（miR-204）位于TRPM3基因内。这种复杂性使得难以清晰了解TRPM3的特性。然而，需要清晰的认识来揭示TRPM3作为实验工具、诊断标志物和治疗靶点的全部潜力。因此，必须尽快讨论并梳理与TRPM3相关的最新数据，以跟上时代并加速从实验室到临床的转化。本综述的目的是突出近期的研究成果和进展，特别关注涉及啮齿动物和人类眼组织、细胞或外周神经元的研究结果。
