Department of Psychiatry, The University of Western Ontario, London, ON, Canada.
Department of Obstetrics & Gynecology, The University of Western Ontario, London, ON, Canada.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):9532-9535. doi: 10.1080/14767058.2022.2046730. Epub 2022 Mar 3.
Hyperemesis gravidarum is a rare but potentially serious complication of pregnancy. Some women with severe symptoms and possibly psychiatric comorbidities remain symptomatic despite the use of currently available treatments. Due to its favorable safety profile, antiemetic efficacy in other conditions, and 5-HT3 antagonism, olanzapine may be a potentially useful addition to the armamentarium for management of hyperemesis gravidarum resistant to standard- of-care treatment.
妊娠剧吐是一种罕见但可能严重的妊娠并发症。一些有严重症状且可能存在精神共病的女性尽管使用了目前可用的治疗方法，但仍有症状。由于奥氮平具有良好的安全性、在其他疾病中的止吐疗效和 5-HT3 拮抗作用，因此对于标准治疗抵抗的妊娠剧吐，奥氮平可能是一种有用的治疗选择。
