Toxicology and Laboratory Animal Science Department, Fidelta Ltd., Zagreb, Croatia;
Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
In Vivo. 2022 Mar-Apr;36(2):635-642. doi: 10.21873/invivo.12747.
BACKGROUND/AIM: This study aimed to investigate the analgesic effects of fluoxetine on Lewis rats of both sexes in the adjuvant-induced arthritis (AIA) rat model. In humans, chronic pain syndromes typical of rheumatoid arthritis (RA) co-exist with depression which is often treated with fluoxetine antidepressant known to have antinociceptive effects.
The experiment was terminated on day 26, after seven days of oral treatment (days 19-25) with fluoxetine and indomethacin. The effects of treatments were assessed on the final day of the study through measuring body weight, serum concentrations of a1-acid glycoprotein, visual arthritis assessment and post mortem histopathology assessment.
Statistically significant difference was determined in the body weight of male subjects, with indomethacin-treated animals putting on significantly more weight than the vehicle and fluoxetine-treated counterparts. No differences were found between the different treatment groups in other study assessments.
The present study did not provide support for analgesic effects of fluoxetine aimed at reducing the severity of the AIA model.
背景/目的：本研究旨在探讨氟西汀对佐剂性关节炎（AIA）大鼠模型中雌雄 Lewis 大鼠的镇痛作用。在人类中，类风湿关节炎（RA）的慢性疼痛综合征常与抑郁症并存，而氟西汀作为一种常用于治疗抑郁症的抗抑郁药，已知具有镇痛作用。
实验于第 26 天结束，在口服氟西汀和吲哚美辛治疗 7 天后（第 19-25 天）。在研究的最后一天通过测量体重、血清 a1-酸性糖蛋白浓度、视觉关节炎评估和死后组织病理学评估来评估治疗效果。
雄性大鼠的体重存在统计学显著差异，与 vehicle 和氟西汀治疗组相比，吲哚美辛治疗组的动物体重明显增加。在其他研究评估中，不同治疗组之间没有发现差异。
本研究未提供支持氟西汀镇痛作用的证据，其目的是减轻 AIA 模型的严重程度。
