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少突胶质前体细胞通过调节轴突重塑塑造视觉系统。

Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.

作者信息

Xiao Yan, Petrucco Luigi, Hoodless Laura J, Portugues Ruben, Czopka Tim

机构信息

Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.

Max Planck Institute of Neurobiology, Sensorimotor Control Research Group, Martinsried, Germany.

出版信息

Nat Neurosci. 2022 Mar;25(3):280-284. doi: 10.1038/s41593-022-01023-7. Epub 2022 Mar 3.

DOI:10.1038/s41593-022-01023-7
PMID:35241802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8904260/
Abstract

Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.

摘要

许多少突胶质前体细胞（OPC）不会分化形成髓磷脂，这表明该细胞群体具有其他作用。斑马鱼视顶盖在无髓磷脂的区域含有OPC。消除这些OPC会损害视网膜神经节细胞轴突分支大小在视网膜顶盖连接形成和成熟过程中的精确控制，并降低视觉刺激的功能处理能力。因此，OPC独立于其形成髓磷脂的经典作用来微调神经回路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ea/8904260/904165996fc4/41593_2022_1023_Fig10_ESM.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ea/8904260/c19716d95ecf/41593_2022_1023_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ea/8904260/17cd9b6a71d3/41593_2022_1023_Fig8_ESM.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2ea/8904260/904165996fc4/41593_2022_1023_Fig10_ESM.jpg

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