Campbell J R, Hoffman S L, Leksana B, Kurniawan L, Marwoto H A
Am J Trop Med Hyg. 1986 Jul;35(4):708-10. doi: 10.4269/ajtmh.1986.35.708.
Sera from tropical splenomegaly syndrome (TSS) and non-TSS patients from the same village were examined for their ability to inhibit the in vitro growth of Plasmodium falciparum. Using synchronized malaria cultures, sera from both groups inhibited parasite development only if added before merozoite reinvasion of erythrocytes had occurred. There was no significant difference in the degree or apparent mechanism of inhibition caused by TSS and non-TSS sera. These results suggest that the aberrant immune response that results in TSS may not be associated with the elaboration of unique serum factors that differentially inhibit growth of the parasite in vitro.
检测了来自同一村庄的热带脾肿大综合征（TSS）患者和非TSS患者的血清抑制恶性疟原虫体外生长的能力。使用同步化的疟疾培养物，两组患者的血清只有在疟原虫裂殖子重新侵入红细胞之前加入才会抑制寄生虫发育。TSS和非TSS血清所引起的抑制程度或明显机制没有显著差异。这些结果表明，导致TSS的异常免疫反应可能与产生独特的血清因子无关，这些血清因子在体外对寄生虫生长的抑制作用存在差异。
