伪装成原发性眼部疾病的转移性神经内分泌肿瘤。
Metastatic neuroendocrine tumors mimicking as primary ocular disease.
作者信息
Shen Alice, Haghighi Arezu, Liang Tom, Lee On-Tat, Gange William, DeBoer Charles, Akhter Mashal, Saber Maria Sibug, Patel Vivek R, Berry Jesse L, Gokoffski Kimberly Kinga
机构信息
Los Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
出版信息
Am J Ophthalmol Case Rep. 2022 Feb 15;26:101425. doi: 10.1016/j.ajoc.2022.101425. eCollection 2022 Jun.
PURPOSE
To report two cases of metastatic neuroendocrine tumors masquerading as primary ocular disease.
OBSERVATIONS
Case 1 is a 38-year-old man who was referred with subacute onset diplopia and fluctuating ptosis suggestive of myasthenia gravis. Case 2 is a 21-year-old man who presented with blurry vision and was found to have a pigmented ciliary body mass and retinal detachment suggestive of uveal melanoma. Both patients were ultimately diagnosed with metastatic neuroendocrine tumors.
CONCLUSIONS AND IMPORTANCE
Neuroendocrine tumors, though rare and infrequently metastatic to the eye and orbit, can initially present with ocular signs. A broad differential and careful consideration of ocular and systemic symptoms are critical in such challenging cases.
目的
报告两例伪装成原发性眼病的转移性神经内分泌肿瘤病例。
观察结果
病例1为一名38岁男性，因亚急性起病的复视和波动性上睑下垂就诊，提示重症肌无力。病例2为一名21岁男性，因视力模糊就诊，发现有色素性睫状体肿物和视网膜脱离，提示葡萄膜黑色素瘤。两名患者最终均被诊断为转移性神经内分泌肿瘤。
结论与重要性
神经内分泌肿瘤虽然罕见且很少转移至眼和眼眶，但最初可表现为眼部体征。在这类具有挑战性的病例中，进行广泛的鉴别诊断并仔细考虑眼部和全身症状至关重要。
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